Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database.

Autor: Choi J; Department of Urology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea., Lee J; Department of Applied Statistics, Chung-Ang University, Seoul, Korea., Hwang YB; Department of Applied Statistics, Chung-Ang University, Seoul, Korea., Jeong BC; Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee S; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea., Ku JH; Department of Urology, Seoul National University College of Medicine, Seoul, Korea., Nam JK; Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea., Kim W; Department of Urology, Ewha Womans University Mokdong Hospital, Seoul, Korea., Lee JY; Department of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Hong SH; Department of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Rha KH; Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Han WK; Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Ham WS; Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Kang SG; Department of Urology, Korea University College of Medicine, Seoul, Korea., Kang SH; Department of Urology, Korea University College of Medicine, Seoul, Korea., Oh JJ; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea., Lee YG; Department of Urology, Hallym University School of Medicine, Seoul, Korea., Kwon TG; Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea., Kim TH; Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea., Jeon SH; Department of Urology, KyungHee University College of Medicine, Seoul, Korea., Lee SH; Department of Urology, KyungHee University College of Medicine, Seoul, Korea., Park SY; Department of Urology, Hanyang University College of Medicine, Seoul, Korea., Yoon YE; Department of Urology, Hanyang University College of Medicine, Seoul, Korea., Lee YS; Department of Urology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea. yongslee@cau.ac.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 08; Vol. 14 (1), pp. 10550. Date of Electronic Publication: 2024 May 08.
DOI: 10.1038/s41598-024-61005-6
Abstrakt: To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8 months. The cohort was divided into two groups: smokers (n = 351) and non-smokers (n = 398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n = 274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (p = 0.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p = 0.322), nor did it increase the readmission rate (p = 0.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR) = 0.87, interquartile range (IQR): 0.54-1.42; p = 0.589] and recurrence-free survival (RFS) (HR = 1.12, IQR: 0.83-1.53; p = 0.458) following RARC for MIBC. The extent of preoperative smoking (≤ 10, 10-30, and ≥ 30 pack-years) had no significant influence on OS and RFS in any of the categories (all p > 0.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC.
(© 2024. The Author(s).)
Databáze: MEDLINE
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