High-frequency photoacoustic and ultrasound imaging for skin evaluation: Pilot study for the assessment of a chemical burn.

Autor: Benavides-Lara J; The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA., Siegel AP; The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA., Tsoukas MM; Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois, USA., Avanaki K; The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA.; Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois, USA.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Jul; Vol. 17 (7), pp. e202300460. Date of Electronic Publication: 2024 May 08.
DOI: 10.1002/jbio.202300460
Abstrakt: Skin architecture and its underlying vascular structure could be used to assess the health status of skin. A non-invasive, high resolution and deep imaging modality able to visualize skin subcutaneous layers and vasculature structures could be useful for determining and characterizing skin disease and trauma. In this study, a multispectral high-frequency, linear array-based photoacoustic/ultrasound (PAUS) probe is developed and implemented for the imaging of rat skin in vivo. The study seeks to demonstrate the probe capabilities for visualizing the skin and its underlying structures, and for monitoring changes in skin structure and composition during a 5-day course of a chemical burn. We analayze composition of lipids, water, oxy-hemoglobin, and deoxy-hemoglobin (for determination of oxygen saturation) in the skin tissue. The study successfully demonstrated the high-frequency PAUS imaging probe was able to provide 3D images of the rat skin architecture, underlying vasculature structures, and oxygen saturation, water, lipids and total hemoglobin.
(© 2024 The Authors. Journal of Biophotonics published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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