Peripheral 5-HT Mediates Gonadotropin-Inhibitory Hormone-Induced Feeding Behavior and Energy Metabolism Disorder in Chickens via the 5-HT2C Receptor.

Autor:	Song X; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Xu W; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Li Z; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Zhang X; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Liu C; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Han K; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Chen L; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Shi Y; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Xu C; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Han D; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Luo R; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Cao Y; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Li Q; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Yang H; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Lu Q; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Qin J; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Wang X; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Hu C; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China., Li X; College of Animal Science and Technology, Guangxi University, Nanning, China.; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China.
Jazyk:	angličtina
Zdroj:	Neuroendocrinology [Neuroendocrinology] 2024; Vol. 114 (8), pp. 749-774. Date of Electronic Publication: 2024 May 08.
DOI:	10.1159/000539238
Abstrakt:	Introduction: Since the discovery of gonadotropin-inhibitory hormone (GnIH), it has been found to play a critical role in reproduction in vertebrates. Recently, a regulatory role of GnIH in appetite and energy metabolism has emerged, although its precise physiological mechanisms remain unknown. Methods: Thus, the present study evaluated the effects of a single or long-term intraperitoneal GnIH treatment on the food intake, weight, and glucolipid metabolism of chickens, as well as investigating the possible neuroendocrinology factors and mechanisms involved in GnIH-induced obesity and glucolipid metabolism disorder. Results: Our results show that the intraperitoneal administration of GnIH to chickens resulted in a marked body mass increase, hyperlipidemia, hyperglycemia, and glucose intolerance. Subsequently, the results of metabolomics studies and the pharmacological inhibition of the 5-HT2C receptor revealed that blocking the 5-HT2C receptor reinforced the effects of GnIH on food intake, body weight, and blood glucose and lipid levels, resulting in even worse cases of GnIH-induced hyperglycemia, hyperlipidemia, and hepatic lipid deposition. This suggests that, via the 5-HT2C receptor, peripheral 5-HT may act as a negative feedback regulator to interplay with GnIH and jointly control energy balance homeostasis in chickens. Discussion: Our present study provides evidence of cross-talk between GnIH and 5-HT in food intake and energy metabolism at the in vivo pharmacological level, and it proposes a molecular basis for these interactions, suggesting that functional interactions between GnIH and 5-HT may open new avenues for understanding the mechanism of the neuroendocrine network involved in appetite and energy metabolism, as well as providing a new therapeutic strategy to prevent obesity, diabetes, and metabolic disorders. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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