A compared histopathological study on kidneys and eye bulbs in distinct clinical presentations of canine leishmaniasis by Leishmania infantum.

Autor: Dos Santos RC; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil., Estrela-Lima A; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil. aestrela@ufba.br.; Department of Veterinary Anatomy, Pathology, and Clinics, School of Veterinary Medicine and Zootechny, UFBA, Salvador, BA, Brazil. aestrela@ufba.br.; Laboratory of Veterinary Pathology, HOSPMEV, UFBA, Salvador, BA, Brazil. aestrela@ufba.br.; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia, Av. Milton Santos, 500, Salvador, Bahia, Brasil, CEP 40170-110. aestrela@ufba.br., Conrado-Dos-Santos WL; Laboratory of Pathology and Bio-Intervention, Gonçalo Moniz Institute, Oswaldo Cruz Foundation-FIOCRUZ/BA, Salvador, BA, Brazil., Oriá A; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil.; Department of Veterinary Anatomy, Pathology, and Clinics, School of Veterinary Medicine and Zootechny, UFBA, Salvador, BA, Brazil., de Sousa Gonçalves R; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil., Silva DN; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil., Larangeira DF; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil.; Department of Veterinary Anatomy, Pathology, and Clinics, School of Veterinary Medicine and Zootechny, UFBA, Salvador, BA, Brazil.; Laboratory of Veterinary Infectiology - Zoonotic Leishmaniasis Clinic, HOSPMEV, UFBA, Salvador, BA, Brazil., do Socorro Pires E Cruz M; Laboratory of Animal Health, Center of Agrarian Sciences, Federal University of Piauí (UFPI), University Campus Minister Petrônio Portella, Teresina-PI, Brazil., de Pinho FA; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil.; Department of Veterinary Anatomy, Pathology, and Clinics, School of Veterinary Medicine and Zootechny, UFBA, Salvador, BA, Brazil.; Laboratory of Veterinary Infectiology - Zoonotic Leishmaniasis Clinic, HOSPMEV, UFBA, Salvador, BA, Brazil., Barrouin-Melo SM; Teaching Hospital of Veterinary Medicine (HOSPMEV) of the Federal University of Bahia (UFBA), Salvador, BA, Brazil. barrouin@ufba.br.; Department of Veterinary Anatomy, Pathology, and Clinics, School of Veterinary Medicine and Zootechny, UFBA, Salvador, BA, Brazil. barrouin@ufba.br.; Laboratory of Veterinary Infectiology - Zoonotic Leishmaniasis Clinic, HOSPMEV, UFBA, Salvador, BA, Brazil. barrouin@ufba.br.; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia, Av. Milton Santos, 500, Salvador, Bahia, Brasil, CEP 40170-110. barrouin@ufba.br.
Jazyk: angličtina
Zdroj: Veterinary research communications [Vet Res Commun] 2024 Aug; Vol. 48 (4), pp. 2243-2261. Date of Electronic Publication: 2024 May 08.
DOI: 10.1007/s11259-024-10379-z
Abstrakt: Canine leishmaniasis (CanL) caused by Leishmania infantum commonly progresses with renal and ophthalmic lesions associated with active systemic disease. As chronic inflammation related to immune complex deposits is a pathophysiological factor in the development of both glomerulonephritis and uveitis, we aimed to evaluate renal and ocular histopathological lesions and analyze whether they were related to each other and the clinical degree of the disease. For that, we evaluated 15 dogs from CanL-endemic areas. L. infantum PCR-positive dogs were studied according to disease severity into two different groups: Group-1 (G1) had data from seven dogs with mild to moderate CanL and no history of treatment, and G2 was formed with eight dogs with severe to terminal disease that had not responded to CanL treatment. Histopathological analysis of kidneys showed higher frequencies and intensities of glomerular basement membrane thickening (p = 0.026), deposits in glomeruli (p = 0.016), epithelial necrosis (p = 0.020), tubular dilatation (p = 0.003) and interstitial fibrosis (p = 0.04) in G2 dogs than in G1 dogs. Surprisingly, the histopathology of eye bulbs showed a higher frequency and intensity of retinitis (p = 0.019) in G1 dogs than in G2 dogs. The comparative analysis showed that there was no correspondence between histopathological findings in kidneys versus eyes in milder or more severe CanL. Our findings suggested that (1) clinically undetectable eye alterations can be more precocious than those in kidneys in the development of CanL, and (2) the lower frequency of eye lesions and higher frequency of renal lesions in dogs with terminal disease even after treatment indicate that therapy may have been effective in reducing CanL-associated ophthalmic disease but not proportionally in reducing kidney disease.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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