Investigating the pharmacological potential of phytol on experimental models of gastric ulcer in rats.

Autor: Araújo RPN; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., da Silva Freitas FV; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., Nunes DB; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., da Silva Brito AK; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., da Costa DS; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Sousa DP; Pharmaceutical Sciences Department, Federal University of Paraíba, Campus I Lot. Cidade Universitaria, João Pessoa, Paraíba, CEP 58051-900, Brazil., de Cássia Meneses Oliveira R; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil. menesesoliveira@gmail.com., Dos Santos RF; Medicinal Plants Research Center, Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Oct; Vol. 397 (10), pp. 7757-7766. Date of Electronic Publication: 2024 May 08.
DOI: 10.1007/s00210-024-03085-9
Abstrakt: Phytol is a diterpene constituent of many essential oils, belonging to the group of unsaturated acyclic alcohols. Although phytol possesses antimycobacterial and anti-inflammatory effects, no reports of a gastrointestinal action are available from the literature. Due to the well-known shortcomings of classical anti-ulcer drugs (e.g. side effects or relapses), natural products may offer an attractive alternative. In this study, a potential gastroprotective activity of phytol was evaluated using acute and chronic ulcer models in rats. Phytol 12.5, 25 and 50 mg/kg, administered orally 1 h prior to induction of gastric lesions by absolute ethanol, inhibited the lesion area by 96, 90 and 95%, respectively. When lesions were induced by ischemia and reperfusion, phytol 12.5 and 25 mg/kg per os decreased the lesion areas by 89 and 46%, respectively. In the third acute ulcer model (lesions induced by ibuprofen), phytol 12.5 mg/kg reduced the lesion area by 55%. Phytol restored the decreased level of reduced glutathione, the increased levels of myeloperoxidase and malondialdehyde and the decreased levels of catalase and superoxide dismutase in rats with gastric ulcer induced by ethanol to levels obtained in vehicle group. Finally, in a chronic model in which gastric ulcer was induced by acetic acid directly instilled into the stomach, phytol administered orally over a time period of 7 days at 12.5, 25, 50 and 100 mg/kg reduced lesion areas by 84, 81, 83 and 68%. Our data suggest a gastroprotective and cicatrizing effect of phytol, possibly associated with its antioxidant effect.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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