Emotional Stress Induces Adaptive Response in Rat Lymphocytes to Subsequent Ionizing Radiation Exposure.

Autor: Umryukhin PE; Research Centre for Medical Genetics, Moscow, Russia. pavelum@mail.ru.; I. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. pavelum@mail.ru., Mikheeva EN; I. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Mishina UM; I. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Proskurnina EV; Research Centre for Medical Genetics, Moscow, Russia., Malinovskaya EM; Research Centre for Medical Genetics, Moscow, Russia., Martynov AV; Research Centre for Medical Genetics, Moscow, Russia., Ershova ES; Research Centre for Medical Genetics, Moscow, Russia., Veiko NN; Research Centre for Medical Genetics, Moscow, Russia., Kostyuk SV; Research Centre for Medical Genetics, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Mar; Vol. 176 (5), pp. 548-554. Date of Electronic Publication: 2024 May 08.
DOI: 10.1007/s10517-024-06065-4
Abstrakt: We studied the molecular mechanisms of cross-adaptation to ionizing radiation (1 Gy) of lymphocytes isolated from rats subjected to emotional stress. The effects of chronic (CES; various types of stress exposure) and acute (AES; forced swimming) emotional stress in rats on indicators of oxidative stress, cell death, and levels of NRF2 and NOX4 proteins involved in the development of the adaptive response were analyzed in isolated lymphocytes. It was found that stress induced an adaptive response in rat lymphocytes and triggered processes similar to the adaptive response induced by low doses of ionizing radiation: an increase in the level of oxidized DNA and cell death, as well as an increase in the content of NOX4 and NRF2 proteins. In animals subjected to emotional stress, suppressed DNA oxidation in response to irradiation, reduced levels of protective factor NRF2, as well as lymphocyte death were observed.
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Databáze: MEDLINE
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