Guardians Turned Culprits: NETosis and Its Influence on Pulmonary Fibrosis Development.

Autor: Varughese A; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India., Balnadupete A; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India., Ramesh P; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India., Prasad TSK; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India., Nidha AB; Department of Biochemistry, Mangalore University, Mangalagangothri, Konaje, India., Bhandary Y; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India. Yash28bhandary@gmail.com.
Jazyk: angličtina
Zdroj: Molecular biotechnology [Mol Biotechnol] 2024 May 08. Date of Electronic Publication: 2024 May 08.
DOI: 10.1007/s12033-024-01171-0
Abstrakt: Idiopathic pulmonary fibrosis (IPF) is a debilitating, life-threatening irreversible lung disease characterized by the excessive accumulation of fibrotic tissue in the lungs, impairing their function. The exact mechanisms underlying Pulmonary fibrosis (PF) are multifaceted and not yet fully understood. Reports show that during COVID-19 pandemic, PF was dramatically increased due to the hyperactivation of the immune system. Neutrophils and macrophages are the patrolling immune cells that keep the microenvironment balanced. Neutrophil extracellular traps (NETs) are a normal protective mechanism of neutrophils. The chief components of the NETs include DNA, citrullinated histones, and anti-microbial peptides which are released by the activated neutrophils. However, it is becoming increasingly evident that hyperactivation of immune cells can also turn into criminals when it comes to pathological state. Dysregulated NETosis may contribute to sustained inflammation, overactivation of fibroblasts, and ultimately promoting collagen deposition which is the characteristic feature of PF. The role of NETs along with inflammation is attaining greater attention. However, seldom researches are related to the relationship between NETs causing PF. This review highlights the cellular mechanism of NETs-induced pulmonary fibrosis, which could give a better understanding of molecular targets which may be helpful for treating NETs-induced PF.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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