Enzyme-Activatable Near-Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy.

Autor: Cheng Z; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Benson S; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Mendive-Tapia L; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Nestoros E; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Lochenie C; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Seah D; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Chang KY; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK., Feng Y; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, EH4 2XR, Edinburgh, UK., Vendrell M; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU, Edinburgh, UK.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jul 22; Vol. 63 (30), pp. e202404587. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1002/anie.202404587
Abstrakt: Photodynamic therapy is an anti-cancer treatment that requires illumination of photosensitizers to induce local cell death. Current near-infrared organic photosensitizers are built from large and non-modular structures that cannot be tuned to improve safety and minimize off-target toxicity. This work describes a novel chemical platform to generate enzyme-activatable near-infrared photosensitizers. We optimized the Se-bridged hemicyanine scaffold to include caging groups and biocompatible moieties, and generated cathepsin-triggered photosensitizers for effective ablation of human glioblastoma cells. Furthermore, we demonstrated that enzyme-activatable Se-bridged hemicyanines are effective photosensitizers for the safe ablation of microtumors in vivo, creating new avenues in the chemical design of targeted anti-cancer photodynamic therapy agents.
(© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: