Regulation of Oxidative Stress and Apoptosis in Streptozotocin-Induced Diabetic Rats by Egyptian Sidr Honey.

Autor: El-Aarag B; Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, 32512, Egypt.; Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA., Shehata SB; Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, 32512, Egypt., El-Garawani IM; Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Koom, 32512, Egypt., El-Seedi HR; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, 32512, Egypt., Nofal AE; Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Koom, 32512, Egypt.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jul; Vol. 21 (7), pp. e202400351. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1002/cbdv.202400351
Abstrakt: Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over time to severe damage to numerous tissues. The present study aimed to estimate the effect of Egyptian Sidr honey against streptozotocin (STZ)-induced diabetes in rats. Diabetic rats were treated with Sidr honey daily for 4 consecutive weeks. The biochemical profile of blood samples was measured. Furthermore, the activity of antioxidant enzymes, nitric oxide (NO), and malonaldehyde (MDA) were examined in hepatic and pancreatic tissues. Moreover, the expression of Bax, Caspase-3, and Bcl2 proteins were measured. Results revealed that the capability of Sidr honey to decline the elevated blood glucose and fructosamine levels. Also, the honey decreased the levels of NO and MDA. Furthermore, it regulated the antioxidant enzymes activity. Moreover, it reduced the expression levels of Caspase-3 and Bax while increased the Bcl2 level. In conclusion, Sidr honey can regulate hyperglycemia, oxidative stress, apoptosis, and antioxidant enzymes in STZ-induced diabetic rats.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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