Influence of administration timing of San-Huang-Xie-Xin-Tang treatment on attenuating Salmonella enterica serovar Typhimurium infection.

Autor: Chang CH; Department of Traditional Chinese Medicine, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, Taiwan.; Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Wang SC; Department of Traditional Chinese Medicine, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, Taiwan., Lee CY; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Su CH; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan., Lai YJ; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan., Lin WD; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan., Hsu YM; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Jazyk: angličtina
Zdroj: Environmental toxicology [Environ Toxicol] 2024 Sep; Vol. 39 (9), pp. 4298-4307. Date of Electronic Publication: 2024 May 08.
DOI: 10.1002/tox.24322
Abstrakt: Salmonella infections are a serious global health concern, particularly in developing countries, and are further exacerbated by the emergence of antibiotic resistance. San-Huang-Xie-Xin-Tang (SHXXT), a traditional herbal medicine with potent anti-inflammatory properties, has recently gained attention as an alternative treatment. Our study emphasizes on the importance of precise timing in accordance with traditional Chinese medicine principles. A mouse infection model was established while different administration times of SHXXT were recorded for the body weight, clinical scores, bacterial counts in blood, and organs. Additionally, cytokine levels, fatty acids, and amino acids in the serum were also monitored. We found that administering SHXXT 1 day after Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) infection (T1 group) leads to positive outcomes. This includes restoration of body weight, improved clinical scores, and reduced bacterial counts in blood and vital organs. Interferon-gamma levels remained consistently high across all treatment groups 6 days post-infection. However, the T1 group showed exclusive suppression of serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). The timing of administration significantly influenced serum fatty acid concentrations, countering Salmonella-induced disruptions, aligning with TNF-α and IL-1β levels. SHXXT had also restored amino acid profiles disrupted by the infection, with notable effects when administered at the correct timing. Our research highlights SHXXT's potential in treating S. Typhimurium infection, emphasizing the importance of precise timing in line with traditional Chinese medicine principles for effective treatment at different disease stages.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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