Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.

Autor:	Marchi NA; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.; Center for Investigation and Research in Sleep, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland.; Laboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland., Daneault V; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS du Centre-Sud-de-l'Ile-de-Montréal, Montreal, Quebec, Canada., André C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada., Martineau-Dussault MÈ; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada., Baril AA; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Thompson C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada., Montplaisir JY; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada., Gilbert D; Department of Radiology, Radio-oncology and Nuclear Medicine, Université de Montréal, Montreal, Quebec, Canada.; Department of Radiology, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada., Lorrain D; Research Center on Aging, Institut Universitaire de Gériatrie de Sherbrooke, CIUSSS de l'Estrie, Sherbrooke, Quebec, Canada.; Department of Psychology, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Boré A; Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Descoteaux M; Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Carrier J; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada., Gosselin N; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montreal, Quebec, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jun; Vol. 20 (6), pp. 4092-4105. Date of Electronic Publication: 2024 May 08.
DOI:	10.1002/alz.13833
Abstrakt:	Introduction: The limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied. Methods: Polysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55-86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI). OSA measures of interest were the apnea-hypopnea index and composite variables of sleep fragmentation and hypoxemia. Microstructural properties of the cingulum, fornix, and uncinate fasciculus were estimated using free water-corrected diffusion tensor imaging. Results: Higher levels of OSA-related hypoxemia were associated with higher left fornix diffusivities only in participants with MCI. Microstructure of the other white matter tracts was not associated with OSA measures. Higher left fornix diffusivities correlated with poorer episodic verbal memory. Discussion: OSA may contribute to fornix damage and memory dysfunction in MCI. Highlights: Sleep apnea-related hypoxemia was associated with altered fornix integrity in MCI. Altered fornix integrity correlated with poorer memory function. Sleep apnea may contribute to fornix damage and memory dysfunction in MCI. (© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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