Long-term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort.

Autor: Tuffier S; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Zhang J; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Bergmann M; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., So R; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology and Public Health, University College London, London, UK., Napolitano GM; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Cole-Hunter T; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Maric M; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Antic S; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.; The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark., Brandt J; Department of Environmental Science, Aarhus University, Roskilde, Denmark.; iClimate, Interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark., Ketzel M; Department of Environmental Science, Aarhus University, Roskilde, Denmark.; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, UK., Loft S; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Lim YH; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Andersen ZJ; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jun; Vol. 20 (6), pp. 4080-4091. Date of Electronic Publication: 2024 May 08.
DOI: 10.1002/alz.13814
Abstrakt: Introduction: We examined the association of long-term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort.
Methods: Female nurses were followed for dementia incidence (hospital contact or medication prescription) from 1993/1999 to 2020. Air pollution and road traffic noise levels were estimated at nurses' residences, and their associations with dementia were examined using Cox regression models.
Results: Of 25,233 nurses 1409 developed dementia. Particulate matter with a diameter of ≤2.5 µm (PM 2.5 ) was associated with dementia incidence, after adjusting for lifestyle, socioeconomic status, and road traffic noise (hazard ratio [95% confidence interval] 1.35 [1.15-1.59] per interquartile range of 2.6 µg/m 3 ). There was no association of PM2.5 with dementia in physically active nurses. Association with road traffic noise diminished after adjusting for PM₂.₅ (1.02 [0.93-1.11] per 7.6 dB).
Discussion: Long-term exposure to air pollution increases risk of dementia, and physical activity may moderate this risk.
Highlights: Long-term exposure to air pollution was associated with increased risk of dementia among female nurses from the Danish Nurse Cohort. Association of air pollution with dementia was independent of road traffic noise. Association of road traffic noise with dementia diminished after adjusting for air pollution. Physical activity moderated adverse effects of air pollution on dementia.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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