Structural correlations between brain magnetic resonance image-derived phenotypes and retinal neuroanatomy.

Autor: Sun Z; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Zhang B; National Clinical Research Centre for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Smith S; Wellcome Centre for Integrative Neuroimaging (WIN Functional Magnetic Resonance Imaging Building), University of Oxford, Oxford, UK., Atan D; Bristol Eye Hospital, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Khawaja AP; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Stuart KV; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Luben RN; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Biradar MI; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., McGillivray T; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Patel PJ; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Khaw PT; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK., Petzold A; Queen Square Institute of Neurology, University College London, Department of Molecular Neurosciences, Moorfields Eye Hospital and National Hospital for Neurology and Neurosurgery, London, UK.; Departments of Neurology and Ophthalmology and Expertise Center for Neuro-ophthalmology, Amsterdam University Medical Centre, Amsterdam, the Netherlands., Foster PJ; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2024 Jul; Vol. 31 (7), pp. e16288. Date of Electronic Publication: 2024 May 08.
DOI: 10.1111/ene.16288
Abstrakt: Background and Purpose: The eye is a well-established model of brain structure and function, yet region-specific structural correlations between the retina and the brain remain underexplored. Therefore, we aim to explore and describe the relationships between the retinal layer thicknesses and brain magnetic resonance image (MRI)-derived phenotypes in UK Biobank.
Methods: Participants with both quality-controlled optical coherence tomography (OCT) and brain MRI were included in this study. Retinal sublayer thicknesses and total macular thickness were derived from OCT scans. Brain image-derived phenotypes (IDPs) of 153 cortical and subcortical regions were processed from MRI scans. We utilized multivariable linear regression models to examine the association between retinal thickness and brain regional volumes. All analyses were corrected for multiple testing and adjusted for confounders.
Results: Data from 6446 participants were included in this study. We identified significant associations between volumetric brain MRI measures of subregions in the occipital lobe (intracalcarine cortex), parietal lobe (postcentral gyrus), cerebellum (lobules VI, VIIb, VIIIa, VIIIb, and IX), and deep brain structures (thalamus, hippocampus, caudate, putamen, pallidum, and accumbens) and the thickness of the innermost retinal sublayers and total macular thickness (all p < 3.3 × 10 -5 ). We did not observe statistically significant associations between brain IDPs and the thickness of the outer retinal sublayers.
Conclusions: Thinner inner and total retinal thicknesses are associated with smaller volumes of specific brain regions. Notably, these relationships extend beyond anatomically established retina-brain connections.
(© 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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