Ruthenium(II) Polypyridyl Complexes with Benzoxazole Derivatives and Non-Innocent Ligands as Effective Antioxidants in Human Neuroblasts.

Autor: Giacomazzo GE; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Conti L; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Paderni D; Department of Pure and Applied Sciences 'Carlo Bo', University of Urbino, Via della Stazione 4, 61029, Urbino., Italy., Sfragano PS; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Quadrini L; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Macedi E; Department of Pure and Applied Sciences 'Carlo Bo', University of Urbino, Via della Stazione 4, 61029, Urbino., Italy., Andreini C; Istituto Nazionale di Genetica Molecolare-INGM, Via Francesco Sforza 35, 20122, Milano, Italy., Donati C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale Morgagni, 50, 50134, Florence, Italy., Bernacchioni C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale Morgagni, 50, 50134, Florence, Italy., Mulas G; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale Morgagni, 50, 50134, Florence, Italy., Valtancoli B; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Palchetti I; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy., Giorgi L; Department of Pure and Applied Sciences 'Carlo Bo', University of Urbino, Via della Stazione 4, 61029, Urbino., Italy., Fusi V; Department of Pure and Applied Sciences 'Carlo Bo', University of Urbino, Via della Stazione 4, 61029, Urbino., Italy., Cencetti F; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale Morgagni, 50, 50134, Florence, Italy., Giorgi C; Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, FI), Italy.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jul 05; Vol. 30 (38), pp. e202400834. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1002/chem.202400834
Abstrakt: Ruthenium(II) polypyridyl complexes continue to raise increasing interest for the encouraging results in several biomedical areas. Considering their vast chemical-physical repertoire, in particular the possibility to switch from the sensitization of reactive oxygen species (ROS) to ROS-scavenging abilities by tuning the nature of their ligands, it is therefore surprising that their potential as antioxidants has not been largely investigated so far. Herein, we explored the antioxidant behaviour of the novel ruthenium compound [Ru(dbpy)(2,3-DAN)Cl]PF 6 (Ru1), featuring a benzoxazole derivative (dpby=2,6-bis(4-methyl-2-benzoxazolyl)pyridine) and the non-innocent 2,3-diamminonaftalene (2,3-DAN) ligand, along with the reference tpy-containing analogue [Ru(tpy)(2,3-DAN)Cl]PF 6 (Ru2) (tpy=2,2':6',2''-terpyridine). Following the synthesis and the electrochemical characterization, chemical antioxidant assays highlighted the beneficial role of dpby for the ROS-scavenging properties of Ru1. These data have been corroborated by the highest protective effect of Ru1 against the oxidative stress induced in SH-SY5Y human neuroblastoma, which exerts pro-survival and anti-inflammatory actions. The results herein reported highlight the potential of Ru1 as pharmacological tool in neurodegenerative diseases and specially prove that the antioxidant properties of such compounds are likely the result of a non-trivial synergetic action involving the bioactive ligands in their chemical architectures.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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