An Elderly Case of Minimal Change Nephrotic Syndrome: Correlation between Renal Tubular Dysfunction and the Onset of Oliguric Acute Kidney Injury Requiring Hemodialysis.

Autor: Gojo M; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Morimoto C; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Taira S; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Yasukawa M; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Asakawa S; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Nagura M; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Arai S; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Yamazaki O; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Tamura Y; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Shibata S; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Fujigaki Y; Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Case reports in nephrology [Case Rep Nephrol] 2024 Apr 30; Vol. 2024, pp. 1505583. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024).
DOI: 10.1155/2024/1505583
Abstrakt: Several theories have been proposed to explain the development of severe acute kidney injury (AKI) in patients with minimal change nephrotic syndrome (MCNS), but the exact mechanism remains unclear. We encountered an elderly patient with biopsy-proven MCNS who suffered from oliguric AKI, which required hemodialysis at the onset and during the first relapse of nephrotic syndrome. Throughout her relapse, we were able to monitor tubular injury markers, namely, urinary N-acetyl- β -D-glucosaminidase and urinary alpha-1-microglobulin levels. This patient had hypertension. 8.5 years after achieving complete remission, she experienced a relapse of nephrotic syndrome accompanied by AKI, necessitating hemodialysis. The hemodialysis was discontinued after 7 weeks of corticosteroid therapy and cyclosporin A treatment. During this relapse, we observed a correlation between the sudden increase in renal tubular injury markers and proteinuria levels and the progression of severe AKI. Conversely, a reduction in renal tubular injury markers and proteinuria was associated with the resolution of AKI. The abrupt elevation of both tubular injury markers and proteinuria levels suggests a possible breakdown in protein endocytosis in proximal tubular cells. Moreover, it is less likely that the acute reduction in intra-glomerular pressure is the primary cause of tubular injury, as it might result in a decrease in both glomerular filtration rate and proteinuria levels. It is conceivable that massive proteinuria, in conjunction with the patient's clinical characteristics, may contribute to tubular injury, ultimately leading to severe AKI in this patient.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this article.
(Copyright © 2024 Maika Gojo et al.)
Databáze: MEDLINE
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