Exploiting of Green Synthesized Metal Oxide Nanoparticles in the Potentiometric Determination of Metformin Hydrochloride in Pharmaceutical Products.

Autor: Almutairi S; Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia., Alarfaj NA; Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia., Almutairi AM; Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia., El-Tohamy MF; Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Jazyk: angličtina
Zdroj: International journal of analytical chemistry [Int J Anal Chem] 2024 Apr 05; Vol. 2024, pp. 8354311. Date of Electronic Publication: 2024 Apr 05 (Print Publication: 2024).
DOI: 10.1155/2024/8354311
Abstrakt: The advanced and highly functional properties of Al 2 O 3 and NiO nanoparticles promote the widespread use of metal oxides as remarkable electroactive materials for sensing and electrochemical applications. The proposed study describes a comparison of the sensitivity and selectivity of two modified wire membrane sensors enriched with Al 2 O 3 and NiO nanoparticles with conventional wire membranes for the quantification of the antidiabetic drug metformin hydrochloride (MTF). The results show linear relationships of the enriched Al 2 O 3 and NiO nanosensors over the concentration ranges 1.0 × 10 -10 -1.0 × 10 -2  mol L -1 and 1.0 × 10 -6 -1.0 × 10 -2  M for both the modified sensors and the conventional coated wire membrane sensors. The regression equations were E mV  = (52.1 ± 0.5) log (MTF) + 729 for enriched nanometallic oxides, E mV  = (57.04 ± 0.4) log (MTF) + 890.66, and E mV  = (58.27 ± 0.7) log (MTF) + 843.27 with correlation coefficients of 0.9991, 0.9997, and 0.9998 for the aforementioned sensors, respectively. The proposed method was fully validated with respect to the recommendations of the International Union of Pure and Applied Chemistry (IUPAC). The newly functionalized sensors have been successfully used for the determination of MTF in its commercial products.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2024 Shikhah Almutairi et al.)
Databáze: MEDLINE
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