Successful Implementation of Combined Treatment Methods for a Rare Recurrence of Waldenstrom Macroglobulinemia With Extramedullary Lesions.

Autor:	Sokolova IY; Department of Hematology, University Clinical Hospital No.1, Sechenov University, Moscow 119048, Russia., Sokolova SM; Department of Hematology, University Clinical Hospital No.1, Sechenov University, Moscow 119048, Russia., Bochkarnikova OV; Department of Hematology, University Clinical Hospital No.1, Sechenov University, Moscow 119048, Russia., Rasulova AE; Department of Hospital Therapy No.1, Sechenov University, Moscow 119048, Russia., Izmailov TR; Department of Oncology, Federal State Budgetary Institution National Medical and Surgical Center Named After N.I. Pirogov of the Ministry of Health of Russia, Moscow 105203, Russia., Polushkin PV; Federal State Budgetary Institution 'Russian Scientific Center for Roentgen Radiology' of the Ministry of Health of the Russia, Moscow 117997, Russia., Kirichenko YY; Department of Hospital Therapy No.1, Sechenov University, Moscow 119048, Russia., Belenkov YN; Department of Hospital Therapy No.1, Sechenov University, Moscow 119048, Russia., Ilgisonis IS; Department of Hospital Therapy No.1, Sechenov University, Moscow 119048, Russia.
Jazyk:	angličtina
Zdroj:	Journal of clinical medicine research [J Clin Med Res] 2024 Apr; Vol. 16 (4), pp. 189-195. Date of Electronic Publication: 2024 Apr 30.
DOI:	10.14740/jocmr5115
Abstrakt:	A 67-year-old woman was admitted to the Hematology Department in 2014 with complaints of weakness and a low-grade fever. After conducting various tests, it was confirmed that she had Waldenstrom macroglobulinemia. She underwent several rounds of chemotherapy and maintenance therapy with rituximab, which resulted in a good clinical response. However, in 2019, an abnormal growth in the soft tissues of patient's frontal region was discovered, which was diagnosed as lymphoplasmacytic lymphoma. This later progressed to an intracranial lesion. The patient underwent radiation therapy for both the extramedullary and intracranial growths, which had a positive effect. A year later, she developed a lesion in her lymph nodes and soft tissues of her right leg, which was confirmed to be a recurrence of Waldenstrom disease. She underwent further treatment and is currently in complete remission. This case highlights the rare occurrence of relapse in Waldenstrom disease and the challenges in diagnosing extramedullary lesions. It also demonstrates the success of modern treatment approaches using a combination of therapies. Competing Interests: All authors declare that they have no conflict of interest and financial support. (Copyright 2024, Sokolova et al.)
Databáze:	MEDLINE
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