Advances in research on renal injury in paroxysmal nocturnal hemoglobinuria.
| Autor: | Li L; Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, P.R. China.; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, P.R. China., Fu R; Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, P.R. China.; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, P.R. China. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of investigative medicine : the official publication of the American Federation for Clinical Research [J Investig Med] 2024 Dec; Vol. 72 (8), pp. 828-833. Date of Electronic Publication: 2024 Aug 28. |
| DOI: | 10.1177/10815589241254046 |
| Abstrakt: | Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease. Clinical manifestations include intravascular hemolysis, renal dysfunction, fatigue, jaundice, pulmonary hypertension, and so on. Renal injury, as a clinical feature of PNH, is difficult to diagnose and is one of the causes of death in patients with PNH. This article reviews the progress in research on PNH combined with renal injury to improve clinicians' understanding of renal injury in PNH patients, define and judge staging in a timely and accurate manner, enable patients to receive timely and appropriate treatment and reduce mortality. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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