Lactobacillus paracasei subsp. paracasei 2004 improves health and lifespan in Caenorhabditis elegans.

Autor: Kishimoto S; RIKEN Center for Biosystems Dynamics Research (BDR), 2-2-3 Minatojima-Minamimachi, Chuo-Ku, Kobe, 650-0047, Japan., Nono M; RIKEN Center for Biosystems Dynamics Research (BDR), 2-2-3 Minatojima-Minamimachi, Chuo-Ku, Kobe, 650-0047, Japan., Makizaki Y; R&D Center, Biofermin Pharmaceutical Co. Ltd., 7-3-4 Ibukidai-Higashimachi, Nishi-Ku, Kobe, 651-2242, Japan., Tanaka Y; R&D Center, Biofermin Pharmaceutical Co. Ltd., 7-3-4 Ibukidai-Higashimachi, Nishi-Ku, Kobe, 651-2242, Japan., Ohno H; R&D Center, Biofermin Pharmaceutical Co. Ltd., 7-3-4 Ibukidai-Higashimachi, Nishi-Ku, Kobe, 651-2242, Japan., Nishida E; RIKEN Center for Biosystems Dynamics Research (BDR), 2-2-3 Minatojima-Minamimachi, Chuo-Ku, Kobe, 650-0047, Japan. eisuke.nishida@riken.jp., Uno M; RIKEN Center for Biosystems Dynamics Research (BDR), 2-2-3 Minatojima-Minamimachi, Chuo-Ku, Kobe, 650-0047, Japan. masaharu.uno@riken.jp.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 07; Vol. 14 (1), pp. 10453. Date of Electronic Publication: 2024 May 07.
DOI: 10.1038/s41598-024-60580-y
Abstrakt: Recent research has highlighted the importance of the gut microbiome in regulating aging, and probiotics are interventions that can promote gut health. In this study, we surveyed several novel lactic acid bacteria to examine their beneficial effect on organismal health and lifespan in C. elegans. We found that animals fed some lactic acid bacteria, including L. acidophilus 1244 and L. paracasei subsp. paracasei 2004, grew healthy. Supplementation with the lactic acid bacterial strains L. acidophilus 1244 or L. paracasei subsp. paracasei 2004 significantly improved health, including food consumption, motility, and resistance to oxidative stressor, hydrogen peroxide. Our RNA-seq analysis showed that supplementation with L. paracasei subsp. paracasei 2004 significantly increased the expression of daf-16, a C. elegans FoxO homolog, as well as genes related to the stress response. Furthermore, daf-16 deletion inhibited the longevity effect of L. paracasei subsp. paracasei 2004 supplementation. Our results suggest that L. paracasei subsp. paracasei 2004 improves health and lifespan in a DAF-16-dependent manner.
(© 2024. The Author(s).)
Databáze: MEDLINE
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