Stain removal, abrasion and anticaries properties of a novel low abrasion dentifrice containing micro-fibrillated cellulose: in vitro assessments.

Autor: Labib ME; NovaFlux, Inc., Princeton, NJ 08540, USA. Electronic address: labib@novaflux.com., Perazzo A; NovaFlux, Inc., Princeton, NJ 08540, USA., Manganaro JL; NovaFlux, Inc., Princeton, NJ 08540, USA., Tabani Y; NovaFlux, Inc., Princeton, NJ 08540, USA., Durham CJ; Protegera Inc, Madison, WI, USA., Schemehorn BR; Therametric Technologies Inc, Noblesville, IN, USA., McClure HC; Therametric Technologies Inc, Noblesville, IN, USA., Walsh LJ; The University of Queensland School of Dentistry, Herston QLD 4006, Australia.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2024 Jul; Vol. 146, pp. 105038. Date of Electronic Publication: 2024 May 05.
DOI: 10.1016/j.jdent.2024.105038
Abstrakt: Objectives: This laboratory study assessed the performance of a novel fluoride dentifrice containing micro-fibrillated cellulose (MFC) and entrapped silica.
Methods: Removal of extrinsic stains was assessed using the pellicle cleaning ratio (PCR) method, and radioactive dentin abrasivity (RDA) was measured, to calculate a cleaning efficiency index (CEI). Fluoride efficacy was evaluated using widely used remineralization and fluoride uptake methods. The test product (Protegera™) was compared to common dentifrices (Crest - Cavity Protection™ and ProHealth™, Sensodyne Pronamel™, Arm & Hammer™ Advanced Whitening, Crest ProHealth™, and Colgate Optic White™).
Results: The PCR for the MFC dentifrice (141) was comparable to three known marketed stain-removing dentifrices (Arm & Hammer™ Advanced Whitening, Crest ProHealth™, and Colgate Optic White™) but it had a significantly lower RDA (88 ± 6) than 5 other products. This gave it the highest CEI of the tested products (2.0). In a 10-day pH cycling study, the fluoride efficacy of the MFC product was comparable to Sensodyne Pronamel and Crest Cavity Protection. The MFC dentifrice was superior for promoting fluoride uptake into incipient enamel lesions compared to the USP reference dentifrice.
Conclusion: The MFC dentifrice has low abrasion, but despite this, it is highly effective in removing stained pellicle. It also is an efficacious fluoride source when compared to relevant commercially available fluoride dentifrices with high dentin abrasivity.
Clinical Significance: The addition of micro-fibrillated cellulose to a fluoride dentifrice gives a low abrasive product that can effectively remove external stains, and serve as an effective fluoride source. This combination of benefits seems well suited to enamel protection and caries prevention.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mohamed E. Labib, Antonio Perazzo, James L. Manganaro and Yacoob Tabani are employees of NovaFlux, Inc. and consultants to Protegera, Inc. Carmine Durham is the CEO of Protegera, Inc. Bruce R. Schemehorn and Heath C. McClure are employees of Therametric Technologies, Inc. Laurence J Walsh is a consultant to Protegera, Inc. The authors declare no other competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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