Clinical remission in severe asthma: lights and shadows on an ambitious goal.

Autor:	Pelaia C; Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro., Zannoni E; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Milan., Paoletti G; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Milan.; Department of Biomedical Sciences, Humanitas University, Milan., Marzio V; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Milan.; Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy., Heffler E; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Milan.; Department of Biomedical Sciences, Humanitas University, Milan., Carrón-Herrero A; Allergology Department, Ramón y Cajal University Hospital, IRYCIS, Madrid 28034, Spain.
Jazyk:	angličtina
Zdroj:	Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2024 Aug 01; Vol. 24 (4), pp. 230-236. Date of Electronic Publication: 2024 Apr 30.
DOI:	10.1097/ACI.0000000000000991
Abstrakt:	Purpose of Review: The aim of this study was Describe the latest evidence related to the concept of clinical remission in patients with severe asthma, focusing on the lights and shadows of this concept. Recent Findings: The idea of clinical remission in severe asthma patients brings about a significant shift in the way asthma is treated and managed. Although there has yet to be unanimous agreement among various scientific societies on the precise definition, this concept can be extremely useful in advancing the treatment of the disease. Summary: Asthma is a common respiratory condition that affects more than 300 million people globally. It has variable symptoms and severity levels, with about 10% of patients experiencing severe asthma. While there have been advancements in treatment, severe asthma poses significant challenges. Recent approaches have focused on achieving clinical remission, which goes beyond symptom control to address underlying inflammation and biological processes. Clinical remission criteria include the absence of symptoms, reduced medication usage, and normalized inflammatory markers. Various biologic therapies show promise, with some patients achieving remission. However, remission's definition varies globally, hindering standardization and a valid comparison. Standardizing remission criteria and refining predictive factors are crucial for effective asthma management. Overall, achieving clinical remission offers hope for improved long-term outcomes in severe asthma patients. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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