Impact of COVID-19 Infection on Pancreato-Biliary Diseases Requiring Endoscopic Retrograde Cholangiopancreatography.

Autor: Karanfilian B; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Tyberg A; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Sarkar A; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Shahid HM; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Simon A; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Reinoso K; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Bapaye A; Pune Hospital, Pune, India., Gandhi A; Pune Hospital, Pune, India., Gadhikar HP; Pune Hospital, Pune, India., Dorwat S; Pune Hospital, Pune, India., Raina H; Pune Hospital, Pune, India., Ansari J; Pune Hospital, Pune, India., Nieto J; Borland Groover Clinic, Jacksonville, FL, USA., Qadir N; Borland Groover Clinic, Jacksonville, FL, USA., Porfilio MG; Posadas, Posadas, Argentina., Arevalo-Mora M; IECED, Guayaquil, Ecuador., Puga-Tejada M; IECED, Guayaquil, Ecuador., Alcivar-Vasquez J; IECED, Guayaquil, Ecuador., Robles-Medranda C; IECED, Guayaquil, Ecuador., Ardengh JC; Universidad de Ribeirao Preto, Ribeirao Preto, SP, Brazil., Bareket R; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Liao K; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Patel R; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Pimpinelli S; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Gaidhane M; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA., Kahaleh M; Endoscopy, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. mkahaleh@gmail.com.
Jazyk: angličtina
Zdroj: Digestive diseases and sciences [Dig Dis Sci] 2024 Aug; Vol. 69 (8), pp. 3015-3018. Date of Electronic Publication: 2024 May 07.
DOI: 10.1007/s10620-024-08454-1
Abstrakt: Background: Viral infections are known to impact the pancreato-biliary system; however, there are limited data showing that the same is true of COVID-19. Endoscopic retrograde cholangiopancreatography (ERCP) can safely be performed in patients with COVID-19 infection, but outcomes of patients with COVID-19 infections and concomitant pancreatic and biliary disease requiring endoscopic intervention are unknown.
Aims: This study aims to evaluate the severity of pancreaticobiliary diseases and post-ERCP outcomes in COVID-19 patients.
Methods: Patients with pancreato-biliary disease that required inpatient ERCP from five centers in the United States and South America between January 1, 2020, and October 31, 2020 were included. A representative cohort of patients from each month were randomly selected from each site. Disease severity and post-ERCP outcomes were compared between COVID-19 positive and COVID-19 negative patients.
Results: A total of 175 patients were included: 95 COVID positive and 80 COVID negative. Mean CTSI score for the patients who had pancreatitis was higher in COVID-positive cohort by 3.2 points (p < .00001). The COVID-positive group had more cases with severe disease (n = 41) versus the COVID-negative group (n = 2) (p < .00001). Mortality was higher in the COVID-19 positive group (19%) compared to COVID-negative group (7.5%) even though the COVID-19-negative group had higher incidence of malignancy (n = 17, 21% vs n = 7, 7.3%) (p = 0.0455).
Conclusions: This study shows that patients with COVID infection have more severe pancreato-biliary disease and worse post-ERCP outcomes, including longer length of stay and higher mortality rate. These are important considerations when planning for endoscopic intervention.
Clinicaltrials: gov: (NCT05051358).
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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