Biomarkers of gastrointestinal nematodes in beef cattle raised in a tropical area.

Autor: Rodrigues VD; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Borges DGL; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Conde MH; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Freitas MG; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., do Nascimento Ramos CA; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Souza AI; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Reckziegel GH; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Castro Rodrigues D; MSD Saúde Animal, São Paulo, Brazil., Borges FA; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil. fernando.borges@ufms.br.; Laboratório de Doenças Parasitárias, Faculdade de Medicina Veterinária E Zootecnia, Universidade Federal de Mato Grosso Do Sul, Avenida Senador Filinto Müller, Campo Grande, MS, 2443, Brazil. fernando.borges@ufms.br.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2024 May 07; Vol. 123 (5), pp. 207. Date of Electronic Publication: 2024 May 07.
DOI: 10.1007/s00436-024-08228-8
Abstrakt: Biomarkers are specific molecular, histological, or physiological characteristics of normal or pathogenic biological processes and are promising in the diagnosis of gastrointestinal nematodes (GINs). Although some biomarkers have been validated for infection by Ostertagia sp. in cattle raised in temperate regions, there is a lack of information for tropical regions. The aim of this project was to assess potential biomarkers and validate the most promising. In the first study, 36 bovines (Nelore breed) naturally infected by GINs were distributed into two groups: infected (not treated with anthelmintic) and treated (treated with fenbendazole on days 0, 7, 14, 21, 28, 42, and 56). The variables of interest were live weight, fecal egg count, hemogram, serum biochemical markers, phosphorus, gastrin, and pepsinogen. In the second step, pepsinogen was assessed in cattle of the Nelore breed distributed among three groups: infected (not treated with anthelmintic), MOX (treated with moxidectin), and IVM + BZD (treated with ivermectin + albendazole). In the first study, no difference between groups was found for weight, albumin, hematocrit (corpuscular volume [CV]), erythrocytes, or hemoglobin. Negative correlations were found between pepsinogen and both CV and albumin, and albumin was negatively correlated with the percentage of Haemonchus sp. in the fecal culture. Among the biomarkers, only pepsinogen differentiated treated and infected (beginning with the 28th day of the study). In the second study, a reduction in pepsinogen was found after anthelmintic treatment. Therefore, pepsinogen is a promising biomarker of worms in cattle naturally infected by the genera Haemonchus and Cooperia in tropical areas.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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