[Study of antitumor effects of human placenta hydrolysate on PC-3, OAW-42, BT-474 cell cultures].
| Autor: | Gromova OA; Federal Research Center 'Computer Science and Control' of the Russian Academy of Sciences., Filimonova MV; National Medical Research Radiological Centre.; Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological Centre., Torshin IY; Federal Research Center 'Computer Science and Control' of the Russian Academy of Sciences., Frolova DЕ; Federal Research Center 'Computer Science and Control' of the Russian Academy of Sciences.; Ivanovo State Medical University. |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2024 Apr 16; Vol. 96 (3), pp. 266-272. Date of Electronic Publication: 2024 Apr 16. |
| DOI: | 10.26442/00403660.2024.03.202624 |
| Abstrakt: | Aim: To investigate the antitumor effects of human placenta hydrolysate (HPH) peptides on three hormone-dependent human cell lines: prostate adenocarcinoma, breast carcinoma, and ovarian cancer by metabolic analysis of cell cultures. Materials and Methods: The effect of HPH on tumor and control tumor cell lines was evaluated. Study stages: (A) de novo peptide sequencing by collision-induced dissociation mass spectrometry; (B) detection of peptides with anti-tumor properties; (C) expert analysis of the obtained lists of peptides. Results: Dose-dependent cytotoxic effects of HPH on three tumor cell lines are shown: PC-3 (human prostate adenocarcinomas), OAW-42 (human ovarian cancer), BT-474 (human breast carcinomas), and IC Conclusion: The results of the study indicate not only the oncological safety of the HPH used in therapy but also the mild antitumor effects of this HPH at high concentrations. |
| Databáze: | MEDLINE |
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