| Autor: |
Phelps DW; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Environmental and Health Effects of PFAS, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA., Connors AM; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Environmental and Health Effects of PFAS, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.; Toxicology Program, North Carolina State University, Raleigh, NC, USA.; Genetics and Genomics Academy, North Carolina State University, Raleigh, NC, USA., Ferrero G; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Environmental and Health Effects of PFAS, North Carolina State University, Raleigh, NC, USA., DeWitt JC; Center for Environmental and Health Effects of PFAS, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA., Yoder JA; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Environmental and Health Effects of PFAS, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.; Toxicology Program, North Carolina State University, Raleigh, NC, USA.; Genetics and Genomics Academy, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA. |
| Abstrakt: |
Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in a variety of processes and consumer products. Their unique chemical properties make them ubiquitous and persistent environmental contaminants while also making them economically viable and socially convenient. To date, several reviews have been published to synthesize information regarding the immunotoxic effects of PFASs on the adaptive immune system. However, these reviews often do not include data on the impact of these compounds on innate immunity. Here, current literature is reviewed to identify and incorporate data regarding the effects of PFASs on innate immunity in humans, experimental models, and wildlife. Known mechanisms by which PFASs modulate innate immune function are also reviewed, including disruption of cell signaling, metabolism, and tissue-level effects. For PFASs where innate immune data are available, results are equivocal, raising additional questions about common mechanisms or pathways of toxicity, but highlighting that the innate immune system within several species can be perturbed by exposure to PFASs. Recommendations are provided for future research to inform hazard identification, risk assessment, and risk management practices for PFASs to protect the immune systems of exposed organisms as well as environmental health. |
