A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation.

Autor: Downey JE; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Schone HR; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA., Foldes ST; Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ., Greenspon C; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Liu F; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA., Verbaarschot C; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA., Biro D; Department of Neurological Surgery, University of Chicago, Chicago, IL., Satzer D; Department of Neurological Surgery, University of Chicago, Chicago, IL., Moon CH; Department of Radiology, University of Pittsburgh, Pittsburgh, PA., Coffman BA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA., Youssofzadeh V; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI., Fields D; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA., Hobbs TG; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA., Okorokova E; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Tyler-Kabara EC; Department of Neurosurgery, Dell Medical School, University of Texas at Austin, Austin, TX., Warnke PC; Department of Neurological Surgery, University of Chicago, Chicago, IL., Gonzalez-Martinez J; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA., Hatsopoulos NG; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computation Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL., Bensmaia SJ; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computation Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL., Boninger ML; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA., Gaunt RA; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA., Collinger JL; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 28. Date of Electronic Publication: 2024 Apr 28.
DOI: 10.1101/2024.04.26.24306239
Abstrakt: Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain-computer interface to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other brain-computer interface studies to ensure successful placement of stimulation electrodes.
Databáze: MEDLINE