Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait.

Autor:	Alramah T; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait., Cherian P; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait., Al-Khairi I; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait., Abu-Farha M; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.; Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait., Thanaraj TA; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait., Albatineh AN; Faculty of Medicine, Kuwait University, Kuwait City, Kuwait., Safadi F; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.; Rebecca D. Considine Research Institute, Akron Children Hospital, Akron, OH, United States., Ali H; Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Center, Kuwait University, Jabriya, Kuwait., Abdul-Ghani M; Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait.; Division of Diabetes, University of Texas Health Science Center, San Antonio, TX, United States., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Internal Medicine and Endocrinology, Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Al-Mulla F; Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait.; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait., Abubaker J; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Apr 22; Vol. 15, pp. 1392675. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1392675
Abstrakt:	Obesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications. Recent research has highlighted the impact of these conditions on bone health, with a particular focus on the role of sclerostin (SOST), a protein molecule integral to bone metabolism. Elevated circulating levels of SOST have been observed in patients with T2DM compared to healthy individuals. This study aims to examine the circulating levels of SOST in a multiethnic population living in Kuwait and to elucidate the relationship between SOST levels, obesity, T2DM, and ethnic background. The study is a cross-sectional analysis of a large cohort of 2083 individuals living in Kuwait. The plasma level of SOST was measured using a bone panel multiplex assay. The study found a significant increase in SOST levels in individuals with T2DM (1008.3 pg/mL, IQR-648) compared to non-diabetic individuals (710.6 pg/mL, IQR-479). There was a significant gender difference in median SOST levels, with males exhibiting higher levels than females across various covariates (diabetes, IR, age, weight, and ethnicity). Notably, SOST levels varied significantly with ethnicity: Arabs (677.4 pg/mL, IQR-481.7), South Asians (914.6 pg/mL, IQR-515), and Southeast Asians (695.2 pg/mL, IQR-436.8). Furthermore, SOST levels showed a significant positive correlation with gender, age, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, HbA1c, insulin, total cholesterol, triglycerides, HDL, LDL, ALT, and AST (p-Value ≥0.05). South Asian participants, who exhibited the highest SOST levels, demonstrated the most pronounced associations, even after adjusting for age, gender, BMI, and diabetes status (p-Value ≥0.05). The observed correlations of SOST with various clinical parameters suggest its significant role in the diabetic milieu, particularly pronounced in the South Asian population compared to other ethnic groups. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Alramah, Cherian, Al-Khairi, Abu-Farha, Thanaraj, Albatineh, Safadi, Ali, Abdul-Ghani, Tuomilehto, Koistinen, Al-Mulla and Abubaker.)
Databáze:	MEDLINE
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