Impact of Asian and Black Donor and Recipient Ethnicity on the Outcomes After Deceased Donor Kidney Transplantation in the United Kingdom.

Autor:	Hakeem AR; Division of Surgery, Department of Transplantation, St. James's University Hospital, Leeds, United Kingdom., Asthana S; Division of Surgery, Department of Transplantation, St. James's University Hospital, Leeds, United Kingdom., Johnson R; National Health Service Blood and Transplant (NHSBT), Bristol, United Kingdom., Brown C; National Health Service Blood and Transplant (NHSBT), Bristol, United Kingdom., Ahmad N; King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2024 Apr 22; Vol. 37, pp. 12605. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).
DOI:	10.3389/ti.2024.12605
Abstrakt:	Patients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates outcomes of renal allografts from Asian and black donors. The UK Transplant Registry was analysed for adult deceased donor kidney only transplants performed between 2001 and 2015. Asian and black ethnicity patients constituted 12.4% and 6.7% of all deceased donor recipients but only 1.6% and 1.2% of all deceased donors, respectively. Unadjusted survival analysis demonstrated significantly inferior long-term allograft outcomes associated with Asian and black donors, compared to white donors. On Cox-regression analysis, Asian donor and black recipient ethnicities were associated with poorer outcomes than white counterparts, and on ethnicity matching, compared with the white donor-white recipient baseline group and adjusting for other donor and recipient factors, 5-year graft outcomes were significantly poorer for black donor-black recipient, Asian donor-white recipient, and white donor-black recipient combinations in decreasing order of worse unadjusted 5-year graft survival. Increased deceased donation among ethnic minorities could benefit the recipient pool by increasing available organs. However, it may require a refined approach to enhance outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hakeem, Asthana, Johnson, Brown and Ahmad.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu