Midpoint of sleep is associated with sleep quality in older adults with and without symptomatic Alzheimer's disease.

Autor:	Sauers SC; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Toedebusch CD; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Richardson R; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Spira AP; Department of Mental Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA.; The Johns Hopkins Center on Aging and Health, Baltimore, MD, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.; Center on Biological Rhythms and Sleep, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA., Lucey BP; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Center on Biological Rhythms and Sleep, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	Sleep advances : a journal of the Sleep Research Society [Sleep Adv] 2024 Apr 15; Vol. 5 (1), pp. zpae023. Date of Electronic Publication: 2024 Apr 15 (Print Publication: 2024).
DOI:	10.1093/sleepadvances/zpae023
Abstrakt:	Introduction: Disrupted sleep is common in individuals with Alzheimer's disease (AD) and may be a marker for AD risk. The timing of sleep affects sleep-wake activity and is also associated with AD, but little is known about links between sleep architecture and the midpoint of sleep in older adults. In this study, we tested if the midpoint of sleep is associated with different measures of sleep architecture, AD biomarkers, and cognitive status among older adults with and without symptomatic AD. Methods: Participants ( N  = 243) with a mean age of 74 underwent standardized cognitive assessments, measurement of CSF AD biomarkers, and sleep monitoring via single-channel EEG, actigraphy, a home sleep apnea test, and self-reported sleep logs. The midpoint of sleep was defined by actigraphy. Results: A later midpoint of sleep was associated with African-American race and greater night-to-night variability in the sleep midpoint. After adjusting for multiple potential confounding factors, a later sleep midpoint was associated with longer rapid-eye movement (REM) onset latency, decreased REM sleep time, more actigraphic awakenings at night, and higher < 2 Hz non-REM slow-wave activity. Conclusions: Noninvasive in vivo markers of brain function, such as sleep, are needed to track both future risk of cognitive impairment and response to interventions in older adults at risk for AD. Sleep timing is associated with multiple other sleep measures and may affect their utility as markers of AD. The midpoint of sleep may be changed through behavioral intervention and should be taken into account when using sleep as a marker for AD risk. (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.)
Databáze:	MEDLINE
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