Determination of the levels and possible associations of alpha2-macroglobulin with autoantibodies in the serum of patients with various forms of autoimmune thyroiditis.

Autor: Rahimova RR; Azerbaijan Medical University, Baku, Azerbaijan., Efendiyev AM; Azerbaijan Medical University, Baku, Azerbaijan., Shahverdiyeva IJ; Azerbaijan Medical University, Baku, Azerbaijan., Dashdamirova GS; Azerbaijan Medical University, Baku, Azerbaijan., Kerimova IA; Azerbaijan Medical University, Baku, Azerbaijan.
Jazyk: angličtina
Zdroj: Biomeditsinskaia khimiia [Biomed Khim] 2024 Apr; Vol. 70 (2), pp. 125-129.
DOI: 10.18097/PBMC20247002125
Abstrakt: Antibodies to thyroid peroxidase (AB-TPO), antibodies to thyroglobulin (AB-TG), and the content of α2-macroglobulin (α2-MG) have been studied in serum samples of patients with autoimmune thyroiditis (AIT). All the patients were divided into 3 groups depending on age: 25-35, 36-50, 51-65 years. We found a significant change in the thyroid panel parameters in AIT, but without significant changes in the average concentration of α2-MG in the age groups of patients. This may be due to the accumulation and retention of complexes of defective forms of α2-MG in the circulation associated with their decreased ability to bind to receptors.
Databáze: MEDLINE