Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets.

Autor: Bhuin A; Physics Division, School of Advanced Sciences, Vellore Institute of Technology Chennai, Vandalur-Kelambakkam Road, Chennai, Tamil Nadu, 600127, India., Udayakumar S; Medical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chettinad Health City, Kelambakkam, Chennai, 603103, India., Gopalarethinam J; Medical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chettinad Health City, Kelambakkam, Chennai, 603103, India., Mukherjee D; Centre for Fuel Cell Technology (CFCT), International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), IIT-M Research Park, Taramani, Chennai, 600113, India., Girigoswami K; Medical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chettinad Health City, Kelambakkam, Chennai, 603103, India., Ponraj C; Physics Division, School of Advanced Sciences, Vellore Institute of Technology Chennai, Vandalur-Kelambakkam Road, Chennai, Tamil Nadu, 600127, India. caroline.ponraj@vit.ac.in., Sarkar S; Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology Chennai, Vandalur-Kelambakkam Road, Chennai, Tamil Nadu, 600127, India. sujoy.sarkar@vit.ac.in.; Electric Vehicle Incubation, Testing and Research Centre (EVIT-RC), Vellore Institute of Technology Chennai, Vandalur-Kelambakkam Road, Chennai, Tamil Nadu, 600127, India. sujoy.sarkar@vit.ac.in.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 06; Vol. 14 (1), pp. 10406. Date of Electronic Publication: 2024 May 06.
DOI: 10.1038/s41598-024-59842-6
Abstrakt: Active pharmaceutical ingredients have emerged as an environmentally undesirable element because of their widespread exploitation and consequent pollution, which has deleterious effects on living things. In the pursuit of sustainable environmental remediation, biomedical applications, and energy production, there has been a significant focus on two-dimensional materials (2D materials) owing to their unique electrical, optical, and structural properties. Herein, we have synthesized 2D zinc oxide nanosheets (ZnO NSs) using a facile and practicable hydrothermal method and characterized them thoroughly using spectroscopic and microscopic techniques. The 2D nanosheets are used as an efficient photocatalyst for antibiotic (herein, end-user ciprofloxacin (CIP) was used as a model antibiotic) degradation under sunlight. It is observed that ZnO NSs photodegrade ~ 90% of CIP within two hours of sunlight illumination. The molecular mechanism of CIP degradation is proposed based on ex-situ IR analysis. Moreover, the 2D ZNO NSs are used as an antimicrobial agent and exhibit antibacterial qualities against a range of bacterial species, including Escherichia coli, Staphylococcus aureus, and MIC of the bacteria are found to be 5 μg/l and 10 μg/l, respectively. Despite having the biocompatible nature of ZnO, as-synthesized nanosheets have also shown cytotoxicity against two types of cancer cells, i.e. A549 and A375. Thus, ZnO nanosheets showed a nontoxic nature, which can be exploited as promising alternatives in different biomedical applications.
(© 2024. The Author(s).)
Databáze: MEDLINE
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