Differences in risky sexual behaviors and HIV prevalence between men who have sex with men and transgender women in the Midwest Brazil.

Autor:	Cesar GA; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., do Lago BV; Laboratory of Viral Hepatitis, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Institute of Immunobiological Technology (Bio-Manguinhos), Fiocruz, Rio de Janeiro, Brazil., Ortiz Tanaka TS; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Zanini PB; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Bandeira LM; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Puga MAM; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Pires Fernandes FR; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Pinto CS; Secretary of Health of the State of Mato Grosso do Sul, Campo Grande, MS, Brazil., Castro LS; Federal University of Rondonópolis, Rondonópolis, MT, Brazil., Bertolacci-Rocha LG; Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO, Brazil., Dos Santos Fernandes CE; Laboratory of General Pathology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., de Rezende GR; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Motta-Castro ARC; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.; Laboratory of Molecular Virology, Oswaldo Cruz Foundation, Mato Grosso do Sul, Campo Grande, MS, Brazil.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2024 May 06; Vol. 4 (5), pp. e0003061. Date of Electronic Publication: 2024 May 06 (Print Publication: 2024).
DOI:	10.1371/journal.pgph.0003061
Abstrakt:	Men who have sex with men (MSM) and transgender women (TW) are disproportionally affected by HIV infection. This cross-sectional study evaluated the HIV-1/2 prevalence, risk factors and HIV molecular features of MSM and TW from Midwest Brazil. Four hundred and thirty participants (278 MSM and 152 TW) from Mato Grosso do Sul, Brazil, were interviewed and tested for HIV-1/2 infection between November 2011 and September 2013. Participants who were assigned male at birth, older than 18 years old and self-declared as MSM or TW were recruited from LGBT+ associations, as well as public (parks, square, streets, etc) and private [nightclubs, saunas, brothels, etc] places. The prevalence of HIV-1 was 14.4% (9.0% among MSM and 24% among TW; p<0.001). The factor independently associated with HIV-1 infection among MSM was being 30 years-old or older. Among TW, having suffered sexual coercion, lifetime syphilis infection and hepatitis C virus exposure were associated with HIV-1 infection. Phylogenetic analyses classified 65% sequences as subtype B and 35% as possible recombinants. All but one recombinant sample were from TW individuals. High HIV-1 prevalences were observed in both groups, highlighting the urgent need to devise specific HIV interventions targeting these key populations. Notably, TWs are more vulnerable to HIV infection, which was associated with sexual violence and co-infection with other STIs. With regard to MSM, being 30 years old or older was significanty associated to HIV, reinforcing the idea that MSM are less exposed [or exposed later] to STIs than TWs, although MSM are clearly more vulnerable than the general population. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Cesar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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