Outcomes of minimal access retroperitoneal para-aortic lymphadenectomy in patients with locally advanced cervical cancer.

Autor:	Newton C; Gynaecology Oncology, University Hospitals Bristol NHS Foundation trust, Bristol, UK.; University of Bristol, Bristol, UK.; University College London Hospital NHS Foundation Trust, London, UK., Graham R; University College London Hospital NHS Foundation Trust, London, UK., Liberale V; University College London Hospital NHS Foundation Trust, London, UK., Burnell M; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK., Menon U; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK., Mould T; University College London Hospital NHS Foundation Trust, London, UK., Olaitan A; University College London Hospital NHS Foundation Trust, London, UK., Macdonald N; University College London Hospital NHS Foundation Trust, London, UK., Widschwendter M; University College London Hospital NHS Foundation Trust, London, UK.; European Translational Oncology Prevention and Screening Institute, Leopold-Franzens-University of Innsbruck, Austria., Doufekas K; University College London Hospital NHS Foundation Trust, London, UK., McCormack M; University College London Hospital NHS Foundation Trust, London, UK., Mitra A; University College London Hospital NHS Foundation Trust, London, UK., Arora R; University College London Hospital NHS Foundation Trust, London, UK., Manchanda R; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; The Royal London hospital, Barts Health NHS trust, London, UK.; Distinguished Infosys Chair in Oncology, All India institute of medical sciences (AIIMS), New Delhi, India.
Jazyk:	angličtina
Zdroj:	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2024 Dec; Vol. 44 (1), pp. 2344529. Date of Electronic Publication: 2024 May 06.
DOI:	10.1080/01443615.2024.2344529
Abstrakt:	Background: To evaluate outcomes of laparoscopic retroperitoneal para-aortic lymphadenectomy for stage 1b3-3b cervical cancer. Methods: Pathology databases searched for all para-aortic lymphadenectomy cases 2005-2016. Descriptive statistics were used to analyse baseline characteristics, cox models for treatment affect after accounting for variables, and Kaplan Meier curves for survival (STATA v15). Results: 191 patients had 1b3-3b cervical cancer of which 110 patients had Para-aortic lymphadenectomy. 8 (7.3%) patients stage 1b3, 82 (74.6%) stage 2b, and 20 (18.1%) stage 3b cervical cancer. Mean lymph node count 11.7 (SD7.6). The intra-operative and post-operative 30 day complication rates were 8.8% (CI: 4.3%, 15.7%) and 5.3% (CI: 1.9%, 11.2%) respectively.Para-aortic nodes were apparently positive on CT/MRI in 5/110 (5%) cases. Cancer was found in 10 (8.9%, CI: 4.3%, 15.7%) cases on histology, all received extended field radiotherapy. Only 2 were identified on pre-operative CT/MRI imaging. 3 of 10 suspected node-positive cases on CT/MRI had negative histology. Para-aortic lymphadenectomy led to alteration in staging and radiotherapy management in 8 (8%, CI: 3.7%, 14.6%) patients. Mean overall survival 42.81 months (SD = 31.79 months). Survival was significantly higher for women undergoing PAN (50.57 (SD 30.7) months) compared to those who didn't (31.27 (SD 32.5) months). Conclusion: Laparoscopic retroperitoneal para-aortic lymphadenectomy is an acceptable procedure which can guide treatment in women with locally advanced cervical cancer.
Databáze:	MEDLINE
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