Elevating theranostics: The emergence and promise of radiopharmaceutical cell-targeting heterodimers in human cancers.

Autor: Chambers C; Molecular Imaging and Theranostics Center, Columbia, Missouri, USA.; Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, USA.; Department of Chemistry, University of Missouri, Columbia, Missouri, USA., Chitwood B; Molecular Imaging and Theranostics Center, Columbia, Missouri, USA., Smith CJ; Molecular Imaging and Theranostics Center, Columbia, Missouri, USA.; Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, USA.; Department of Radiology, University of Missouri School of Medicine, Columbia, Missouri, USA.; University of Missouri Research Reactor Center, University of Missouri, Columbia, Missouri, USA., Miao Y; Department of Radiology, University of Colorado Denver, Aurora, Colorado, USA.
Jazyk: angličtina
Zdroj: IRadiology [iRadiology] 2024 Apr; Vol. 2 (2), pp. 128-155. Date of Electronic Publication: 2024 Apr 06.
DOI: 10.1002/ird3.62
Abstrakt: Optimal therapeutic and diagnostic efficacy is essential for healthcare's global mission of advancing oncologic drug development. Accurate diagnosis and detection are crucial prerequisites for effective risk stratification and personalized patient care in clinical oncology. A paradigm shift is emerging with the promise of multi-receptor-targeting compounds. While existing detection and staging methods have demonstrated some success, the traditional approach of monotherapy is being reevaluated to enhance therapeutic effectiveness. Heterodimeric site-specific agents are a versatile solution by targeting two distinct biomarkers with a single theranostic agent. This review describes the innovation of dual-targeting compounds, examining their design strategies, therapeutic implications, and the promising path they present for addressing complex diseases.
Competing Interests: CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. If authors are from the editorial board of iRADIOLOGY, they will be excluded from the peer-review process and all editorial decisions related to the publication of this article.
Databáze: MEDLINE
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