Mutational dynamics of SARS-CoV-2: Impact on future COVID-19 vaccine strategies.

Autor:	Faraji N; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Zeinali T; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Joukar F; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Aleali MS; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Eslami N; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Shenagari M; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.; Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Mansour-Ghanaei F; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Apr 25; Vol. 10 (9), pp. e30208. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e30208
Abstrakt:	The rapid emergence of multiple strains of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has sparked profound concerns regarding the ongoing evolution of the virus and its potential impact on global health. Classified by the World Health Organization (WHO) as variants of concern (VOC), these strains exhibit heightened transmissibility and pathogenicity, posing significant challenges to existing vaccine strategies. Despite widespread vaccination efforts, the continual evolution of SARS-CoV-2 variants presents a formidable obstacle to achieving herd immunity. Of particular concern is the coronavirus spike (S) protein, a pivotal viral surface protein crucial for host cell entry and infectivity. Mutations within the S protein have been shown to enhance transmissibility and confer resistance to antibody-mediated neutralization, undermining the efficacy of traditional vaccine platforms. Moreover, the S protein undergoes rapid molecular evolution under selective immune pressure, leading to the emergence of diverse variants with distinct mutation profiles. This review underscores the urgent need for vigilance and adaptation in vaccine development efforts to combat the evolving landscape of SARS-CoV-2 mutations and ensure the long-term effectiveness of global immunization campaigns. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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