Short-term behavioral and histological findings following a single concussive and repeated subconcussive brain injury in a rodent model.
| Autor: | Clay AM; Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi, USA., Carr RL; Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi University, Mississippi, USA., DuBien JL; Department of Statistics, Mississippi University, Mississippi, USA., To F; Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Brain injury [Brain Inj] 2024 Aug 23; Vol. 38 (10), pp. 827-834. Date of Electronic Publication: 2024 May 05. |
| DOI: | 10.1080/02699052.2024.2349144 |
| Abstrakt: | Primary Objective: It is unclear of the correlation between a mild traumatic brain injury (mTBI) and repeated subconcussive (RSC) impacts with respect to injury biomechanics. Thus, the present study was designed to determine the behavioral and histological differences between a single mTBI impact and RSC impacts with subdivided cumulative kinetic energies of the single mTBI impact. Research Design: Adult male Sprague-Dawley rats were randomly assigned to a single mTBI impact, RSC impact, sham, or repeated sham groups. Methods and Procedures: Following a weight drop injury, anxiety-like behavior and general locomotive activity and were assessed using the open field test, while motor coordination was evaluated using a rotarod unit. Neuronal loss, astrogliosis, and microgliosis were assessed using NeuN, GFAP and Iba-1 immunohistochemistry. All assessments were undertaken at 3- and 7-days post impact. Main Outcomes and Results: No behavioral disturbances were observed in injury groups, however, both injury groups did lead to microgliosis following 3-days post-impact. Conclusions: No pathophysiological differences were observed between a single mTBI impact and RSC impacts of the same energy input. Even though a cumulative injury threshold for RSC impacts was not determined, a threshold still may exist where no pathodynamic shift occurs. |
| Databáze: | MEDLINE |
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