Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer's Disease.

Autor: Conca F; ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, Italy., Esposito V; IRCCS Mondino Foundation, Pavia, Italy., Catricalà E; ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, Italy. eleonora.catricala@iusspavia.it., Manenti R; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., L'Abbate F; Neurology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Quaranta D; Neurology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.; Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy., Giuffrè GM; Neurology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Rossetto F; IRCCS Fondazione Don Carlo Gnocchi, ONLUS, Milan, Italy., Solca F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy., Orso B; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Inguscio E; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Crepaldi V; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., De Matteis M; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Rotondo E; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Manera M; Istituti Clinici Scientifici Maugeri IRCCS, Psychology Unit Pavia-Montescano, Pavia Institute, Pavia, Italy., Caruso G; Neuropsychiatric Laboratory, Clinical Neuroscience and Neurorehabilitation Department, IRCCS Fondazione Santa Lucia, Rome, Italy., Catania V; Oasi Research Institute-IRCCS, Troina, Italy., Canu E; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rundo F; Oasi Research Institute-IRCCS, Troina, Italy., Cotta Ramusino M; IRCCS Mondino Foundation, Pavia, Italy., Filippi M; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, Neurophysiology Service, Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Fundarò C; Istituti Clinici Scientifici Maugeri IRCCS, Neurophysiopatology Unit Pavia-Montescano, Pavia Institute, Pavia, Italy., Piras F; Neuropsychiatric Laboratory, Clinical Neuroscience and Neurorehabilitation Department, IRCCS Fondazione Santa Lucia, Rome, Italy., Arighi A; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Tiraboschi P; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Stanzani Maserati M; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Pardini M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico S. Martino, Genoa, Italy., Poletti B; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; 'Dino Ferrari' Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Marra C; Neurology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.; Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy., Di Tella S; Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.; IRCCS Fondazione Don Carlo Gnocchi, ONLUS, Milan, Italy., Cotelli M; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Lodi R; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Tagliavini F; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Cappa SF; ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, Italy.; IRCCS Mondino Foundation, Pavia, Italy.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 May 04; Vol. 16 (1), pp. 98. Date of Electronic Publication: 2024 May 04.
DOI: 10.1186/s13195-024-01465-0
Abstrakt: Background: The identification and staging of Alzheimer's Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts were dedicated to select and harmonize available neuropsychological instruments. In Italy, the Italian Network of Neuroscience and Neuro-Rehabilitation has promoted the adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB), collecting normative data from 433 healthy controls (HC). Here, we aimed to explore the ability of I-UDSNB to differentiate between a) MCI and HC, b) AD and HC, c) MCI and AD.
Methods: One hundred thirty-seven patients (65 MCI, 72 AD) diagnosed after clinical-neuropsychological assessment, and 137 HC were included. We compared the I-UDSNB scores between a) MCI and HC, b) AD and HC, c) MCI and AD, with t-tests. To identify the test(s) most capable of differentiating between groups, significant scores were entered in binary logistic and in stepwise regressions, and then in Receiver Operating Characteristic curve analyses.
Results: Two episodic memory tests (Craft Story and Five Words test) differentiated MCI from HC subjects; Five Words test, Semantic Fluency (vegetables), and TMT-part B differentiated AD from, respectively, HC and MCI.
Conclusions: Our findings indicate that the I-UDSNB is a suitable tool for the harmonized and concise assessment of patients with cognitive decline, showing high sensitivity and specificity for the diagnosis of MCI and AD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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