Progressive multifocal leukoencephalopathy in a patient with B-cell chronic lymphocytic leukemia after COVID-19 vaccination, complicated with COVID-19 and mucormycosis: a case report.

Autor: Amirifard H; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Neurology, Iranian Center of Neurological Research, Tehran University of medical sciences, Imam Khomeini Hospital Complex, Tehran, Iran., Shahbazi M; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Neurology, Iranian Center of Neurological Research, Tehran University of medical sciences, Imam Khomeini Hospital Complex, Tehran, Iran., Farahmand G; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran., Ranjbar Z; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Neurology, Iranian Center of Neurological Research, Tehran University of medical sciences, Imam Khomeini Hospital Complex, Tehran, Iran., Kaeedi M; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Neurology, Iranian Center of Neurological Research, Tehran University of medical sciences, Imam Khomeini Hospital Complex, Tehran, Iran., Heydari Havadaragh S; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. sanazheydari400@gmail.com.; Neurology, Iranian Center of Neurological Research, Tehran University of medical sciences, Imam Khomeini Hospital Complex, Tehran, Iran. sanazheydari400@gmail.com.
Jazyk: angličtina
Zdroj: BMC neurology [BMC Neurol] 2024 May 04; Vol. 24 (1), pp. 151. Date of Electronic Publication: 2024 May 04.
DOI: 10.1186/s12883-024-03650-y
Abstrakt: Background: Progressive multifocal leukoencephalopathy (PML) is a rare and fatal opportunistic viral demyelinating infectious disease of the central nervous system (CNS). There are various clinical presenting symptoms for the disease.
Case Presentation: This paper presents a clinical case of PML in a patient with B-Chronic lymphocytic leukemia (B-CLL), previously treated with Chlorambucil, later complicated later with COVID-19 and mucormycosis.
Conclusion: PML can develop in the setting of cellular immune dysfunction. Late diagnosis of this disease based on nonspecific symptoms is common, therefore when we face a neurological complication in a CLL or immunocompromised patient, we should consider PML infection. A remarkable feature of this case is the possible triggering effect of COVID-19 vaccination for emergence of PML as the disease can be asymptomatic or sub-clinical before diagnosis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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