Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort.

Autor: Braun T; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Feng R; The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.; Department of Gastroenterology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-Sen University, Nanning, Guangxi, China., Amir A; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Levhar N; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Shacham H; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Mao R; The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China., Hadar R; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Toren I; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.; Department of Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Algavi Y; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Abu-Saad K; Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel., Zhuo S; The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China., Efroni G; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Malik A; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Picard O; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Yavzori M; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel., Agranovich B; Laura and Isaac Perlmutter Metabolomics Center, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel., Liu TC; Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St. Louis, MO, USA., Stappenbeck TS; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Denson L; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Kalter-Leibovici O; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel., Gottlieb E; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel., Borenstein E; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel.; Santa Fe Institute, Santa Fe, NM, USA., Elinav E; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.; Microbiome & Cancer Division, German National Cancer Center (DKFZ), Heidelberg, Germany., Chen M; The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China., Ben-Horin S; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Haberman Y; Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel. yael.haberman@cchmc.org.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. yael.haberman@cchmc.org.; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. yael.haberman@cchmc.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 04; Vol. 15 (1), pp. 3764. Date of Electronic Publication: 2024 May 04.
DOI: 10.1038/s41467-024-48106-6
Abstrakt: Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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