Unearthing naturally-occurring cyclic antibacterial peptides and their structural optimization strategies.

Autor: Zeng P; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong., Wang H; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang P; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong., Leung SSY; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: sharon.leung@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Biotechnology advances [Biotechnol Adv] 2024 Jul-Aug; Vol. 73, pp. 108371. Date of Electronic Publication: 2024 May 03.
DOI: 10.1016/j.biotechadv.2024.108371
Abstrakt: Natural products with antibacterial activity are highly desired globally to combat against multidrug-resistant (MDR) bacteria. Antibacterial peptide (ABP), especially cyclic ABP (CABP), is one of the abundant classes. Most of them were isolated from microbes, demonstrating excellent bactericidal effects. With the improved proteolytic stability, CABPs are normally considered to have better druggability than linear peptides. However, most clinically-used CABP-based antibiotics, such as colistin, also face the challenges of drug resistance soon after they reached the market, urgently requiring the development of next-generation succedaneums. We present here a detail review on the novel naturally-occurring CABPs discovered in the past decade and some of them are under clinical trials, exhibiting anticipated application potential. According to their chemical structures, they were broadly classified into five groups, including (i) lactam/lactone-based CABPs, (ii) cyclic lipopeptides, (iii) glycopeptides, (iv) cyclic sulfur-rich peptides and (v) multiple-modified CABPs. Their chemical structures, antibacterial spectrums and proposed mechanisms are discussed. Moreover, engineered analogs of these novel CABPs are also summarized to preliminarily analyze their structure-activity relationship. This review aims to provide a global perspective on research and development of novel CABPs to highlight the effectiveness of derivatives design in identifying promising antibacterial agents. Further research efforts in this area are believed to play important roles in fighting against the multidrug-resistance crisis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: