Optical coherence elastography with osmotically induced strains: Preliminary demonstration for express detection of cartilage degradation.

Autor: Alexandrovskaya YM; Terra Quantum GmbH, Munich, Germany., Kasianenko EM; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia.; National Research Center Kurchatov Institute, Moscow, Russia., Sovetsky AA; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia., Matveyev AL; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia., Atyakshin DA; Scientific and Educational Resource Center 'Molecular Morphology', RUDN University, Moscow, Russia., Patsap OI; Scientific and Educational Resource Center 'Molecular Morphology', RUDN University, Moscow, Russia., Ignatiuk MA; Scientific and Educational Resource Center 'Molecular Morphology', RUDN University, Moscow, Russia., Volodkin AV; Scientific and Educational Resource Center 'Molecular Morphology', RUDN University, Moscow, Russia., Zaitsev VY; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Jul; Vol. 17 (7), pp. e202400016. Date of Electronic Publication: 2024 May 04.
DOI: 10.1002/jbio.202400016
Abstrakt: Optical coherence elastography (OCE) demonstrated impressive abilities for diagnosing tissue types/states using differences in their biomechanics. Usually, OCE visualizes tissue deformation induced by some additional stimulus (e.g., contact compression or auxiliary elastic-wave excitation). We propose a new variant of OCE with osmotically induced straining (OIS-OCE) and demonstrate its application to assess various stages of proteoglycan content degradation in cartilage. The information-bearing signatures in OIS-OCE are the magnitude and rate of strains caused by the application of osmotically active solutions onto the sample surface. OCE examination of the induced strains does not require special tissue preparation, the osmotic stimulation is highly reproducible, and strains are observed in noncontact mode. Several minutes suffice to obtain a conclusion. These features are promising for intraoperative method usage when express assessment of tissue state is required during surgical operations. The "waterfall" images demonstrate the development of cumulative osmotic strains in control and degraded cartilage samples.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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