The role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies.

Autor: Chesney KM; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, USA., Keating GF; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, USA., Patel N; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, USA., Kilburn L; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Fonseca A; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Wu CC; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA., Nazarian J; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Packer RJ; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Donoho DA; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Oluigbo C; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Myseros JS; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Keating RF; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Syed HR; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA. syedhr@gmail.com.; Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC, USA. syedhr@gmail.com.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2024 Aug; Vol. 40 (8), pp. 2333-2344. Date of Electronic Publication: 2024 May 03.
DOI: 10.1007/s00381-024-06413-9
Abstrakt: Introduction: Focused ultrasound (FUS) is an innovative and emerging technology for the treatment of adult and pediatric brain tumors and illustrates the intersection of various specialized fields, including neurosurgery, neuro-oncology, radiation oncology, and biomedical engineering.
Objective: The authors provide a comprehensive overview of the application and implications of FUS in treating pediatric brain tumors, with a special focus on pediatric low-grade gliomas (pLGGs) and the evolving landscape of this technology and its clinical utility.
Methods: The fundamental principles of FUS include its ability to induce thermal ablation or enhance drug delivery through transient blood-brain barrier (BBB) disruption, emphasizing the adaptability of high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) applications.
Results: Several ongoing clinical trials explore the potential of FUS in offering alternative therapeutic strategies for pathologies where conventional treatments fall short, specifically centrally-located benign CNS tumors and diffuse intrinsic pontine glioma (DIPG). A case illustration involving the use of HIFU for pilocytic astrocytoma is presented.
Conclusion: Discussions regarding future applications of FUS for the treatment of gliomas include improved drug delivery, immunomodulation, radiosensitization, and other technological advancements.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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