Clinical characterization and detection of subclinical atherosclerosis in subjects with extreme hyperalphalipoproteinemia.

Autor:	Espíldora-Hernández J; Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Málaga, España; Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), Universidad de Málaga, Málaga, España. Electronic address: javierespildora@gmail.com., Díaz-Antonio T; Servicio de Radiodiagnóstico., Hospital Universitario Virgen de la Victoria, Málaga, España., Olmedo-Llanes J; Servicio de Medicina Interna, Hospital de Antequera, Málaga, España., Zarzuela León J; Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Málaga, España., Rioja J; Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Málaga, España; Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), Universidad de Málaga, Málaga, España., Valdivielso P; Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Málaga, España; Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), Universidad de Málaga, Málaga, España; Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Málaga, España., Sánchez-Chaparro MÁ; Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Málaga, España; Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), Universidad de Málaga, Málaga, España; Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Málaga, España., Ariza MJ; Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico Sanitarias (CIMES), Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), Universidad de Málaga, Málaga, España; Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Málaga, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Clin Investig Arterioscler] 2024 May 02. Date of Electronic Publication: 2024 May 02.
DOI:	10.1016/j.arteri.2024.03.005
Abstrakt:	Introduction and Objectives: The association between HDL cholesterol (HDL-C) levels and death from cardiovascular disease follows a U-shaped pattern, increasing at the extremes. The objective of the study was to characterize a sample of subjects with extreme hyperalphalipoproteinemia (HAE). Material and Methods: 53 cases with HAE were recruited, 24 women (HDL-C>135mg/ dL) and 29 men (HDL-C>116mg/ dL). A detailed medical history was taken and questionnaires on adherence to the Mediterranean diet and physical activity were collected. Carotid ultrasounds were performed to detect the presence of suclinical atherosclerosis. Results: The most prevalent cardiovascular risk factor (CVRF) was dyslipidemia (64%) with no significant differences between men and women, unlike hypertension (21% in women, versus 55% in men, p=0.01) and others CVRF, for example, diabetes. 7% of the series had previous cardiovascular disease, women had higher LDL cholesterol (p=0.002) and HDL-C than men (without significant differences). Plaque was detected in 53% of cases, being more prevalent in men. Patients with plaque were older, drank more alcohol and smoked more (p<0.05). Conclusions: Men had a higher prevalence of CVRF than women, except for dyslipidemia. Subclinical atherosclerosis occurred in more than half of the series. Age, alcohol consumption and smoking were independently associated with the presence of plaque, however, our data do not show a significant influence of HDL-C levels. (Copyright © 2024. Publicado por Elsevier España, S.L.U.)
Databáze:	MEDLINE
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