Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy.

Autor: Heaugwane D; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France., Cerlati O; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France., Belkhir K; ICGM, Université de Montpellier, CNRS, ENSCM, Montpellier, France., Tarek Benkhaled B; ICGM, Université de Montpellier, CNRS, ENSCM, Montpellier, France., Catrouillet S; ICGM, Université de Montpellier, CNRS, ENSCM, Montpellier, France., Fabing I; Laboratoire SPCMIB, CNRS UMR5068, Université Toulouse III - Paul Sabatier, 118 Rte de Narbonne, 31062 Toulouse cedex 9, France., Claparols C; Institut de Chimie de Toulouse, Université Toulouse 3 Paul Sabatier, ICT-FR CNRS 2599, 31062 Toulouse France., Vedrenne M; Institut de Chimie de Toulouse, Université Toulouse 3 Paul Sabatier, ICT-FR CNRS 2599, 31062 Toulouse France., Goudounèche D; CMEAB Université Toulouse III - Paul Sabatier, 133 Route de Narbonne, 31062 Toulouse cedex, France., Payré B; CMEAB Université Toulouse III - Paul Sabatier, 133 Route de Narbonne, 31062 Toulouse cedex, France., Lucia Bona B; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milan, Italy., Tosi A; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milan, Italy., Baldelli Bombelli F; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milan, Italy., Vicendo P; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France., Lapinte V; ICGM, Université de Montpellier, CNRS, ENSCM, Montpellier, France., Lonetti B; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France., Mingotaud AF; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France. Electronic address: anne-francoise.mingotaud@cnrs.fr., Gibot L; Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier, 31062 Toulouse, France. Electronic address: laure.gibot@cnrs.fr.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Jun 10; Vol. 658, pp. 124186. Date of Electronic Publication: 2024 May 01.
DOI: 10.1016/j.ijpharm.2024.124186
Abstrakt: Because of the difficult challenges of nanopharmaceutics, the development of a variety of nanovectors is still highly desired. Photodynamic therapy, which uses a photosensitizer to locally produce reactive oxygen species to kill the undesired cells, is a typical example for which encapsulation has been shown to be beneficial. The present work describes the use of coumarin-functionalized polymeric nanovectors based on the self-assembly of amphiphilic poly(2-oxazoline)s. Encapsulation of pheophorbide a, a known PDT photosensitizer, is shown to lead to an increased efficiency compared to the un-encapsulated version. Interestingly, the presence of coumarin both enhances the desired photocytotoxicity and enables the crosslinking of the vectors. Various nanovectors are examined, differing by their size, shape and hydrophilicity. Their behaviour in PDT protocols on HCT-116 cells monolayers is described, the influence of their crosslinking commented. Furthermore, the formation of a protein corona is assessed.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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