Different heart rate variability profile during sleep in mid-later life adults with remitted early-onset versus late-onset depression.

Autor: Kong SDX; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia; Charles Perkins Centre, University of Sydney, Camperdown, NSW 2050, Australia; CogSleep, Australian National Health and Medical Research Council Centre of Research Excellence, Australia. Electronic address: dexiao.kong@sydney.edu.au., Espinosa N; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia., McKinnon AC; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia; Charles Perkins Centre, University of Sydney, Camperdown, NSW 2050, Australia; Race Against Dementia, Dementia Australia Research Foundation Initiative, Dementia Australia, Australia., Gordon CJ; CogSleep, Australian National Health and Medical Research Council Centre of Research Excellence, Australia; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Glebe, NSW 2037, Australia; Faculty of Medicine and Health, Royal North Shore Hospital, Sydney 2050, Australia., Wassing R; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Glebe, NSW 2037, Australia; School of Psychological Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Sydney Local Health District, Sydney, NSW, Australia., Hoyos CM; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Glebe, NSW 2037, Australia; School of Psychological Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Hickie IB; Youth Mental Health Team, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia., Naismith SL; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia; Charles Perkins Centre, University of Sydney, Camperdown, NSW 2050, Australia; CogSleep, Australian National Health and Medical Research Council Centre of Research Excellence, Australia.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Aug 01; Vol. 358, pp. 175-182. Date of Electronic Publication: 2024 May 01.
DOI: 10.1016/j.jad.2024.04.054
Abstrakt: Background: In mid-later life adults, early-onset and late-onset (i.e., onset ≥50 years) depression appear to be underpinned by different pathophysiology yet have not been examined in relation to autonomic function. Sleep provides an opportunity to examine the autonomic nervous system as the physiology changes across the night. Hence, we aimed to explore if autonomic profile is altered in mid-later life adults with remitted early-onset, late-onset and no history of lifetime depression.
Methods: Participants aged 50-90 years (n = 188) from a specialised clinic underwent a comprehensive clinical assessment and completed an overnight polysomnography study. General Linear Models were used to examine the heart rate variability differences among the three groups for four distinct sleep stages and the wake after sleep onset. All analyses controlled for potential confounders - age, sex, current depressive symptoms and antidepressant usage.
Results: For the wake after sleep onset, mid-later life adults with remitted early-onset depression had reduced standard deviation of Normal to Normal intervals (SDNN; p = .014, d = -0.64) and Shannon Entropy (p = .004, d = -0.46,) than those with no history of lifetime depression. Further, the late-onset group showed a reduction in high-frequency heart rate variability (HF n.u.) during non-rapid eye movement sleep stage 2 (N2; p = .005, d = -0.53) and non-rapid eye movement sleep stage 3 (N3; p = .009, d = -0.55) when compared to those with no lifetime history.
Limitations: Causality between heart rate variability and depression cannot be derived in this cross-sectional study. Longitudinal studies are needed to examine the effects remitted depressive episodes on autonomic function.
Conclusion: The findings suggest differential autonomic profile for remitted early-onset and late-onset mid-later life adults during sleep stages and wake periods. The differences could potentially serve as peripheral biomarkers in conjunction with more disease-specific markers of depression to improve diagnosis and prognosis.
Competing Interests: Declaration of competing interest Professor Ian Hickie is the Co-Director, Health and Policy at the Brain and Mind Centre (BMC) University of Sydney. The BMC operates an early-intervention youth services at Camperdown under contract to headspace. He is the Chief Scientific Advisor to, and a 3.2 % equity shareholder in, InnoWell Pty Ltd. InnoWell was formed as a joint venture by the University of Sydney (32 % equity) and PwC (Australia; 32 % equity) to deliver the $30 m Australian Government-funded Project Synergy (2017-20; a three-year program for the transformation of mental health services) and to lead transformation of mental health services internationally through the use of innovative technologies. The remaining authors have no conflicts of interest to declare.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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