| Autor: |
Chen Q; Department of Tuberculosis, 900TH Hospital of Joint Logistics Support Force, Fuzhou, 350025, China., Li J; Department of Tuberculosis, 900TH Hospital of Joint Logistics Support Force, Fuzhou, 350025, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Future microbiology [Future Microbiol] 2024 Jul 02; Vol. 19 (10), pp. 877-888. Date of Electronic Publication: 2024 May 03. |
| DOI: |
10.2217/fmb-2023-0237 |
| Abstrakt: |
Aim: This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. Materials & methods: Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. Results: Five hub genes ( PIK3R1 , IL1A , CXCR4 , ACTN1 , PFN1 ) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors RELA , JUN , NFKB1 and FOS that regulated hub genes modulated IL1A expression, while 21 other transcription factors regulated CXCR4 expression. Conclusion: In summary, this study may provide new insights into the mechanisms of CF with NTM infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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