The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO study.
Autor: | Spencer S; Arizona State University., Harker SA; Arizona State University., Barry F; Rhode Island Hospital, Brown University., Beauchemin J; Rhode Island Hospital, Brown University., Braden BB; Arizona State University., Burton P; Rhode Island Hospital, Brown University., D'sa V; Rhode Island Hospital, Brown University., Koinis-Mitchell D; Rhode Island Hospital, Brown University., Mennenga SE; Arizona State University., Deoni SCL; Rhode Island Hospital, Brown University., Lewis CR; Arizona State University. |
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Jazyk: | angličtina |
Zdroj: | Research square [Res Sq] 2024 Apr 19. Date of Electronic Publication: 2024 Apr 19. |
DOI: | 10.21203/rs.3.rs-4139933/v1 |
Abstrakt: | Epigenetic processes, including DNA methylation, are emerging as key areas of interest for their potential roles as biomarkers and contributors to the risk of neurodevelopmental, psychiatric, and other brain-based disorders. Despite this growing focus, there remains a notable gap in our understanding of how DNA methylation correlates with individual variations in brain function and structure. Additionally, the dynamics of these relationships during developmental periods, which are critical windows during which many disorders first appear, are still largely unexplored. The current study extends the field by examining if peripheral DNA methylation of myelination-related genes predicts white matter volume in a healthy pediatric population [N = 250; females = 113; age range 2 months-14 years; M Competing Interests: Additional Declarations: No competing interests reported. Competing interests The authors have no conflict of interest to disclose. Supplementary Files This is a list of supplementary files associated with this preprint. Click to download. • SupplementalInformation.docx |
Databáze: | MEDLINE |
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