Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk.

Autor: Alhobeira HA; Department of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia., Sharma A; Department of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India. profanamika091@gmail.com., Sharma A; Department of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India., Khan M; Department of Biology, College of Science, University of Ha'il, Ha'il 55473, Saudi Arabia., Lohani M; Medical Research Centre, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia., Khan S; Department of Basic Dental and Medical Sciences, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia., Fahmy EK; Physiology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia., Esmaeel SE; Physiology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia., Agarwal A; Pathology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2024 Aug; Vol. 193 (4), pp. 1949-1955. Date of Electronic Publication: 2024 May 03.
DOI: 10.1007/s11845-024-03695-5
Abstrakt: Background: Cytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells.
Materials and Methods: Herein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.
Results: Patients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.
Conclusion: NST is a cost-effective and accessible cancer prevention procedure for general dentists.
(© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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