Muscle mass as a modifier of stress response in acute ischemic stroke patients.

Autor: Arsava EM; Department of Neurology, Faculty of Medicine, Hacettepe University, 06230, Altindag, Ankara, Turkey. arsavaem@hotmail.com., Gungor L; Department of Neurology, Ondokuz Mayis University, Samsun, Turkey., Sirin H; Department of Neurology, Ege University, Izmir, Turkey., Sorgun MH; Department of Neurology, Ankara University, Ankara, Turkey., Aykac O; Department of Neurology, Eskisehir Osmangazi University, Eskisehir, Turkey., Batur Caglayan HZ; Department of Neurology, Gazi University, Ankara, Turkey., Kozak HH; Department of Neurology, Necmettin Erbakan University, Konya, Turkey., Ozturk S; Department of Neurology, Selcuk University, Konya, Turkey., Topcuoglu MA; Department of Neurology, Faculty of Medicine, Hacettepe University, 06230, Altindag, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 02; Vol. 14 (1), pp. 10088. Date of Electronic Publication: 2024 May 02.
DOI: 10.1038/s41598-024-60829-6
Abstrakt: Stroke triggers a systemic inflammatory response over the ensuing days after the cerebral insult. The age and comorbidities of the stroke population make them a vulnerable population for low muscle mass and sarcopenia, the latter being another clinical condition that is closely associated with inflammation, as shown by increased levels of pro-inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR). In this study, we evaluated the relationship between post-stroke NLR changes and muscle mass in a prospective cohort of acute ischemic stroke patients (n = 102) enrolled in the Muscle Assessment in Stroke Study Turkey (MASS-TR). Admission lumbar computed tomography images were used to determine the cross-sectional muscle area of skeletal muscles at L3 vertebra level and calculate the skeletal muscle index (SMI). The median (IQR) SMI was 44.7 (39.1-52.5) cm 2 /m 2 , and the NLR at admission and follow-up were 4.2 (3.0-10.5) and 9.4 (5.7-16.2), respectively. While there was no relationship between SMI and admission NLR, a significant inverse correlation was observed between SMI and follow-up NLR (r =  - 0.26; P = 0.007). Lower SMI remained significantly associated (P = 0.036) with higher follow-up NLR levels in multivariate analysis. Our findings highlight the importance of muscle mass as a novel factor related to the level of post-stroke stress response.
(© 2024. The Author(s).)
Databáze: MEDLINE
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