Subthalamic nucleus synchronization between beta band local field potential and single-unit activity in Parkinson's disease.

Autor: Bayman E; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Chee K; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Mendlen M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Denman DJ; Department of Neurophysiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Tien RN; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Ojemann S; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kramer DR; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Thompson JA; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2024 May; Vol. 12 (9), pp. e16001.
DOI: 10.14814/phy2.16001
Abstrakt: Local field potential (LFP) oscillations in the beta band (13-30 Hz) in the subthalamic nucleus (STN) of Parkinson's disease patients have been implicated in disease severity and treatment response. The relationship between single-neuron activity in the STN and regional beta power changes remains unclear. We used spike-triggered average (STA) to assess beta synchronization in STN. Beta power and STA magnitude at the beta frequency range were compared in three conditions: STN versus other subcortical structures, dorsal versus ventral STN, and high versus low beta power STN recordings. Magnitude of STA-LFP was greater within the STN compared to extra-STN structures along the trajectory path, despite no difference in percentage of the total power. Within the STN, there was a higher percent beta power in dorsal compared to ventral STN but no difference in STA-LFP magnitude. Further refining the comparison to high versus low beta peak power recordings inside the STN to evaluate if single-unit activity synchronized more strongly with beta band activity in areas of high beta power resulted in a significantly higher STA magnitude for areas of high beta power. Overall, these results suggest that STN single units strongly synchronize to beta activity, particularly units in areas of high beta power.
(© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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